Publications

Showing records 1 - 20 (of 139)

Publication: Book Item (Buchkap., Lexikonartikel, jur. Kommentierung, Beiträge in Sammelbänden etc.)

ID	Author	Year	Title	Publisher
4498837	Boss, C.; Wittlin, S.	2018	Recent trends in malaria research	Division of Medicinal Chemistry

Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	Author	Year	Title	Publisher
4596372	Burgert, Lydia; Rottmann, Matthias; Wittlin, Sergio; Gobeau, Nathalie; Krause, Andreas; Dingemanse, Jasper; Möhrle, Jörg J.; Penny, Melissa A.	2020	Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development	Scientific reports
3178807	Phillips, Margaret A.; Lotharius, Julie; Marsh, Kennan; White, John; Dayan, Anthony; White, Karen L.; Njoroge, Jacqueline W.; El Mazouni, Farah; Lao, Yanbin; Kokkonda, Sreekanth; Tomchick, Diana R.; Deng, Xiaoyi; Laird, Trevor; Bhatia, Sangeeta N.; March, Sandra; Ng, Caroline L.; Fidock, David A.; Wittlin, Sergio; Lafuente-Monasterio, Maria; Gamo Benito, Francisco Javier; Sanz Alonso, Laura Maria; Santos Martinez, Maria; Belen Jimenez-Diaz, Maria; Ferrer Bazaga, Santiago; Angulo-Barturen, Inigo; Haselden, John N.; Louttit, James; Cui, Yi; Sridhar, Arun; Zeeman, Anna-Marie; Kocken, Clemens; Sauerwein, Robert; Dechering, Koen; Avery, Vicky M.; Duffy, Sandra; Delves, Michael; Sinden, Robert; Ruecker, Andrea; Wickham, Kristina S.; Rochford, Rosemary; Gahagen, Janet; Iyer, Lalitha; Riccio, Ed; Mirsalis, Jon; Bathhurst, Ian; Rueckle, Thomas; Ding, Xavier; Campo, Brice; Leroy, Didier; Rogers, M. John; Rathod, Pradipsinh K.; Burrows, Jeremy N.; Charman, Susan A.	2015	A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria	Science translational medicine
4514042	Schalkwijk, Joost; Allman, Erik L.; Jansen, Patrick A. M.; de Vries, Laura E.; Verhoef, Julie M. J.; Jackowski, Suzanne; Botman, Peter N. M.; Beuckens-Schortinghuis, Christien A.; Koolen, Karin M. J.; Bolscher, Judith M.; Vos, Martijn W.; Miller, Karen; Reeves, Stacy A.; Pett, Helmi; Trevitt, Graham; Wittlin, Sergio; Scheurer, Christian; Sax, Sibylle; Fischli, Christoph; Angulo-Barturen, Iñigo; Jiménez-Diaz, Mariá Belén; Josling, Gabrielle; Kooij, Taco W. A.; Bonnert, Roger; Campo, Brice; Blaauw, Richard H.; Rutjes, Floris P. J. T.; Sauerwein, Robert W.; Llinás, Manuel; Hermkens, Pedro H. H.; Dechering, Koen J.	2019	Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum	Science Translational Medicine
4651924	Xie, S. C.; Metcalfe, R. D.; Dunn, E.; Morton, C. J.; Huang, S. C.; Puhalovich, T.; Du, Y.; Wittlin, S.; Nie, S.; Luth, M. R.; Ma, L.; Kim, M. S.; Pasaje, C. F. A.; Kumpornsin, K.; Giannangelo, C.; Houghton, F. J.; Churchyard, A.; Famodimu, M. T.; Barry, D. C.; Gillett, D. L.; Dey, S.; Kosasih, C. C.; Newman, W.; Niles, J. C.; Lee, M. C. S.; Baum, J.; Ottilie, S.; Winzeler, E. A.; Creek, D. J.; Williamson, N.; Parker, M. W.; Brand, S.; Langston, S. P.; Dick, L. R.; Griffin, M. D. W.; Gould, A. E.; Tilley, L.	2022	Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy	Science
4646227	Murithi, J. M.; Pascal, C.; Bath, J.; Boulenc, X.; Gnadig, N. F.; Pasaje, C. F. A.; Rubiano, K.; Yeo, T.; Mok, S.; Klieber, S.; Desert, P.; Jimenez-Diaz, M. B.; Marfurt, J.; Rouillier, M.; Cherkaoui-Rbati, M. H.; Gobeau, N.; Wittlin, S.; Uhlemann, A. C.; Price, R. N.; Wirjanata, G.; Noviyanti, R.; Tumwebaze, P.; Cooper, R. A.; Rosenthal, P. J.; Sanz, L. M.; Gamo, F. J.; Joseph, J.; Singh, S.; Bashyam, S.; Augereau, J. M.; Giraud, E.; Bozec, T.; Vermat, T.; Tuffal, G.; Guillon, J. M.; Menegotto, J.; Salle, L.; Louit, G.; Cabanis, M. J.; Nicolas, M. F.; Doubovetzky, M.; Merino, R.; Bessila, N.; Angulo-Barturen, I.; Baud, D.; Bebrevska, L.; Escudie, F.; Niles, J. C.; Blasco, B.; Campbell, S.; Courtemanche, G.; Fraisse, L.; Pellet, A.; Fidock, D. A.; Leroy, D.	2021	The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance	Sci Transl Med
4501060	Baragaña, Beatriz; Forte, Barbara; Choi, Ryan; Nakazawa Hewitt, Stephen; Bueren-Calabuig, Juan A.; Pisco, João Pedro; Peet, Caroline; Dranow, David M.; Robinson, David A.; Jansen, Chimed; Norcross, Neil R.; Vinayak, Sumiti; Anderson, Mark; Brooks, Carrie F.; Cooper, Caitlin A.; Damerow, Sebastian; Delves, Michael; Dowers, Karen; Duffy, James; Edwards, Thomas E.; Hallyburton, Irene; Horst, Benjamin G.; Hulverson, Matthew A.; Ferguson, Liam; Jiménez-Díaz, María Belén; Jumani, Rajiv S.; Lorimer, Donald D.; Love, Melissa S.; Maher, Steven; Matthews, Holly; McNamara, Case W.; Miller, Peter; O'Neill, Sandra; Ojo, Kayode K.; Osuna-Cabello, Maria; Pinto, Erika; Post, John; Riley, Jennifer; Rottmann, Matthias; Sanz, Laura M.; Scullion, Paul; Sharma, Arvind; Shepherd, Sharon M.; Shishikura, Yoko; Simeons, Frederick R. C.; Stebbins, Erin E.; Stojanovski, Laste; Straschil, Ursula; Tamaki, Fabio K.; Tamjar, Jevgenia; Torrie, Leah S.; Vantaux, Amélie; Witkowski, Benoît; Wittlin, Sergio; Yogavel, Manickam; Zuccotto, Fabio; Angulo-Barturen, Iñigo; Sinden, Robert; Baum, Jake; Gamo, Francisco-Javier; Mäser, Pascal; Kyle, Dennis E.; Winzeler, Elizabeth A.; Myler, Peter J.; Wyatt, Paul G.; Floyd, David; Matthews, David; Sharma, Amit; Striepen, Boris; Huston, Christopher D.; Gray, David W.; Fairlamb, Alan H.; Pisliakov, Andrei V.; Walpole, Chris; Read, Kevin D.; Van Voorhis, Wesley C.; Gilbert, Ian H.	2019	Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis	Proceedings of the National Academy of Sciences of the United States of America
1023082	Charman, Susan A; Arbe-Barnes, Sarah; Bathurst, Ian C; Brun, Reto; Campbell, Michael; Charman, William N; Chiu, Francis C K; Chollet, Jacques; Craft, J Carl; Creek, Darren J; Dong, Yuxiang; Matile, Hugues; Maurer, Melanie; Morizzi, Julia; Nguyen, Tien; Papastogiannidis, Petros; Scheurer, Christian; Shackleford, David M; Sriraghavan, Kamaraj; Stingelin, Lukas; Tang, Yuanqing; Urwyler, Heinrich; Wang, Xiaofang; White, Karen L; Wittlin, Sergio; Zhou, Lin; Vennerstrom, Jonathan L	2011	Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria	Proceedings of the National Academy of Sciences of the United States of America
4646024	Xie, S. C.; Metcalfe, R. D.; Mizutani, H.; Puhalovich, T.; Hanssen, E.; Morton, C. J.; Du, Y.; Dogovski, C.; Huang, S. C.; Ciavarri, J.; Hales, P.; Griffin, R. J.; Cohen, L. H.; Chuang, B. C.; Wittlin, S.; Deni, I.; Yeo, T.; Ward, K. E.; Barry, D. C.; Liu, B.; Gillett, D. L.; Crespo-Fernandez, B. F.; Ottilie, S.; Mittal, N.; Churchyard, A.; Ferguson, D.; Aguiar, A. C. C.; Guido, R. V. C.; Baum, J.; Hanson, K. K.; Winzeler, E. A.; Gamo, F. J.; Fidock, D. A.; Baud, D.; Parker, M. W.; Brand, S.; Dick, L. R.; Griffin, M. D. W.; Gould, A. E.; Tilley, L.	2021	Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome	Proc Natl Acad Sci U S A
4665602	Walz, A.; Duffey, M.; Aljayyoussi, G.; Sax, S.; Leroy, D.; Besson, A.; Burrows, J. N.; Cherkaoui-Rbati, M. H.; Gobeau, N.; Westwood, M.-A.; Siethoff, C.; Gamo, S.; Mäser, P.; Wittlin, S.	2023	The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro	Pharmaceuticals (Basel)
524438	Abiodun, Oyindamola O.; Gbotosho, Grace O.; Ajaiyeoba, Edith O.; Happi, Christian T.; Hofer, Sandra; Wittlin, Sergio; Sowunmi, Akin; Brun, Reto; Oduola, Ayoade M. J.	2010	Comparison of SYBR Green I-, PicoGreen-, and [H-3]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine	Parasitology research : Organ der Deutschen Gesellschaft für Parasitologie
1634874	Wenzler, Tanja; Steinhuber, Andrea; Wittlin, Sergio; Scheurer, Christian; Brun, Reto; Trampuz, Andrej	2012	Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum	PLoS neglected tropical diseases
3642646	Le Bihan, Amélie; de Kanter, Ruben; Angulo-Barturen, Iñigo; Binkert, Christoph; Boss, Christoph; Brun, Reto; Brunner, Ralf; Buchmann, Stephan; Burrows, Jeremy; Dechering, Koen J; Delves, Michael; Ewerling, Sonja; Ferrer, Santiago; Fischli, Christoph; Gamo-Benito, Francisco Javier; Gnädig, Nina F; Heidmann, Bibia; Jiménez-Díaz, María Belén; Leroy, Didier; Martínez, Maria Santos; Meyer, Solange; Moehrle, Joerg J; Ng, Caroline L; Noviyanti, Rintis; Ruecker, Andrea; Sanz, Laura María; Sauerwein, Robert W; Scheurer, Christian; Schleiferboeck, Sarah; Sinden, Robert; Snyder, Christopher; Straimer, Judith; Wirjanata, Grennady; Marfurt, Jutta; Price, Ric N; Weller, Thomas; Fischli, Walter; Fidock, David A; Clozel, Martine; Wittlin, Sergio	2016	Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling	PLoS medicine
1635031	Delves, Michael; Plouffe, David; Scheurer, Christian; Meister, Stephan; Wittlin, Sergio; Winzeler, Elizabeth A; Sinden, Robert E; Leroy, Didier	2012	The activities of current antimalarial drugs on the life cycle stages of Plasmodium : a comparative study with human and rodent parasites	PLoS medicine
4646370	Hitz, E.; Wiedemar, N.; Passecker, A.; Graça, B. A. S.; Scheurer, C.; Wittlin, S.; Brancucci, N. M. B.; Vakonakis, I.; Mäser, P.; Voss, T. S.	2021	The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites	PLoS Biol
3768462	Krieg, Reimar; Jortzik, Esther; Goetz, Alice-Anne; Blandin, Stéphanie; Wittlin, Sergio; Elhabiri, Mourad; Rahbari, Mahsa; Nuryyeva, Selbi; Voigt, Kerstin; Dahse, Hans-Martin; Brakhage, Axel; Beckmann, Svenja; Quack, Thomas; Grevelding, Christoph G.; Pinkerton, Anthony B.; Schönecker, Bruno; Burrows, Jeremy; Davioud-Charvet, Elisabeth; Rahlfs, Stefan; Becker, Katja	2017	Arylmethylamino steroids as antiparasitic agents	Nature communications
533261	Kelly, Jane X; Smilkstein, Martin J; Brun, Reto; Wittlin, Sergio; Cooper, Roland A; Lane, Kristin D; Janowsky, Aaron; Johnson, Robert A; Dodean, Rozalia A; Winter, Rolf; Hinrichs, David J; Riscoe, Michael K	2009	Discovery of dual function acridones as a new antimalarial chemotype	Nature
3154657	Baragana, Beatriz; Hallyburton, Irene; Lee, Marcus C. S.; Norcross, Neil R.; Grimaldi, Raffaella; Otto, Thomas D.; Proto, William R.; Blagborough, Andrew M.; Meister, Stephan; Wirjanata, Grennady; Ruecker, Andrea; Upton, Leanna M.; Abraham, Tara S.; Almeida, Mariana J.; Pradhan, Anupam; Porzelle, Achim; Santos Martinez, Maria; Bolscher, Judith M.; Woodland, Andrew; Norval, Suzanne; Zuccotto, Fabio; Thomas, John; Simeons, Frederick; Stojanovski, Laste; Osuna-Cabello, Maria; Brock, Paddy M.; Churcher, Tom S.; Sala, Katarzyna A.; Zakutansky, Sara E.; Belen Jimenez-Diaz, Maria; Maria Sanz, Laura; Riley, Jennifer; Basak, Rajshekhar; Campbell, Michael; Avery, Vicky M.; Sauerwein, Robert W.; Dechering, Koen J.; Noviyanti, Rintis; Campo, Brice; Frearson, Julie A.; Angulo-Barturen, Inigo; Ferrer-Bazaga, Santiago; Javier Gamo, Francisco; Wyatt, Paul G.; Leroy, Didier; Siegl, Peter; Delves, Michael J.; Kyle, Dennis E.; Wittlin, Sergio; Marfurt, Jutta; Price, Ric N.; Sinden, Robert E.; Winzeler, Elizabeth A.; Charman, Susan A.; Bebrevska, Lidiya; Gray, David W.; Campbell, Simon; Fairlamb, Alan H.; Willis, Paul A.; Rayner, Julian C.; Fidock, David A.; Read, Kevin D.; Gilbert, Ian H.	2015	A novel multiple-stage antimalarial agent that inhibits protein synthesis	Nature
533352	Nyongbela, Kennedy; Ndjoko, Karine Ioset; Brun, Reto; Wittlin, Sergio; Mbah, James; Makolo, Felix; Akam, Marc; Wirmum, Claire; Efange, Simon; Hostettmann, Kurt	2009	Occurrence of sesquiterpene derivatives in Scleria striatonux de wild (Cyperaceae)	Natural product communications : NPC
4651529	de Vries, L. E.; Jansen, P. A. M.; Barcelo, C.; Munro, J.; Verhoef, J. M. J.; Pasaje, C. F. A.; Rubiano, K.; Striepen, J.; Abla, N.; Berning, L.; Bolscher, J. M.; Demarta-Gatsi, C.; Henderson, R. W. M.; Huijs, T.; Koolen, K. M. J.; Tumwebaze, P. K.; Yeo, T.; Aguiar, A. C. C.; Angulo-Barturen, I.; Churchyard, A.; Baum, J.; Fernandez, B. C.; Fuchs, A.; Gamo, F. J.; Guido, R. V. C.; Jimenez-Diaz, M. B.; Pereira, D. B.; Rochford, R.; Roesch, C.; Sanz, L. M.; Trevitt, G.; Witkowski, B.; Wittlin, S.; Cooper, R. A.; Rosenthal, P. J.; Sauerwein, R. W.; Schalkwijk, J.; Hermkens, P. H. H.; Bonnert, R. V.; Campo, B.; Fidock, D. A.; Llinas, M.; Niles, J. C.; Kooij, T. W. A.; Dechering, K. J.	2022	Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183	Nat Commun

Showing records 1 - 20 (of 139)