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de Vries, L. E.; Jansen, P. A. M.; Barcelo, C.; Munro, J.; Verhoef, J. M. J.; Pasaje, C. F. A.; Rubiano, K.; Striepen, J.; Abla, N.; Berning, L.; Bolscher, J. M.; Demarta-Gatsi, C.; Henderson, R. W. M.; Huijs, T.; Koolen, K. M. J.; Tumwebaze, P. K.; Yeo, T.; Aguiar, A. C. C.; Angulo-Barturen, I.; Churchyard, A.; Baum, J.; Fernandez, B. C.; Fuchs, A.; Gamo, F. J.; Guido, R. V. C.; Jimenez-Diaz, M. B.; Pereira, D. B.; Rochford, R.; Roesch, C.; Sanz, L. M.; Trevitt, G.; Witkowski, B.; Wittlin, S.; Cooper, R. A.; Rosenthal, P. J.; Sauerwein, R. W.; Schalkwijk, J.; Hermkens, P. H. H.; Bonnert, R. V.; Campo, B.; Fidock, D. A.; Llinas, M.; Niles, J. C.; Kooij, T. W. A.; Dechering, K. J.
2022
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183
Younis, Yassir; Douelle, Frederic; González Cabrera, Diego; Le Manach, Claire; Nchinda, Aloysius T.; Paquet, Tanya; Street, Leslie J.; White, Karen L.; Zabiulla, K. Mohammed; Joseph, Jayan T.; Bashyam, Sridevi; Waterson, David; Witty, Michael J.; Wittlin, Sergio; Charman, Susan A.; Chibale, Kelly
2013
Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity
Younis, Y.; Douelle, F.; Feng, T. S.; Cabrera, D. G.; Manach, C. L.; Nchinda, A. T.; Duffy, S.; White, K. L.; Shackleford, D. M.; Morizzi, J.; Mannila, J.; Katneni, K.; Bhamidipati, R.; Zabiulla, K. M.; Joseph, J. T.; Bashyam, S.; Waterson, D.; Witty, M. J.; Hardick, D.; Wittlin, S.; Avery, V.; Charman, S. A.; Chibale, K.
2012
3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential
Xie, S. C.; Metcalfe, R. D.; Mizutani, H.; Puhalovich, T.; Hanssen, E.; Morton, C. J.; Du, Y.; Dogovski, C.; Huang, S. C.; Ciavarri, J.; Hales, P.; Griffin, R. J.; Cohen, L. H.; Chuang, B. C.; Wittlin, S.; Deni, I.; Yeo, T.; Ward, K. E.; Barry, D. C.; Liu, B.; Gillett, D. L.; Crespo-Fernandez, B. F.; Ottilie, S.; Mittal, N.; Churchyard, A.; Ferguson, D.; Aguiar, A. C. C.; Guido, R. V. C.; Baum, J.; Hanson, K. K.; Winzeler, E. A.; Gamo, F. J.; Fidock, D. A.; Baud, D.; Parker, M. W.; Brand, S.; Dick, L. R.; Griffin, M. D. W.; Gould, A. E.; Tilley, L.
2021
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome
Xie, S. C.; Metcalfe, R. D.; Dunn, E.; Morton, C. J.; Huang, S. C.; Puhalovich, T.; Du, Y.; Wittlin, S.; Nie, S.; Luth, M. R.; Ma, L.; Kim, M. S.; Pasaje, C. F. A.; Kumpornsin, K.; Giannangelo, C.; Houghton, F. J.; Churchyard, A.; Famodimu, M. T.; Barry, D. C.; Gillett, D. L.; Dey, S.; Kosasih, C. C.; Newman, W.; Niles, J. C.; Lee, M. C. S.; Baum, J.; Ottilie, S.; Winzeler, E. A.; Creek, D. J.; Williamson, N.; Parker, M. W.; Brand, S.; Langston, S. P.; Dick, L. R.; Griffin, M. D. W.; Gould, A. E.; Tilley, L.
2022
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
Wang, X.; Dong, Y.; Wittlin, S.; Charman, S. A.; Chiu, F. C.; Chollet, J.; Katneni, K.; Mannila, J.; Morizzi, J.; Ryan, E.; Scheurer, C.; Steuten, J.; Santo, Tomas J.; Snyder, C.; Vennerstrom, J. L.
2013
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs : relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity
Bioorganic & medicinal chemistry letters : a Tetrahedron publication for the rapid dissemination of preliminary communications on all aspects of bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines
