Publications

Showing records 1 - 20 (of 139)

Publication: Book Item (Buchkap., Lexikonartikel, jur. Kommentierung, Beiträge in Sammelbänden etc.)

ID	Author	Year	Title	Publisher
4498837	Boss, C.; Wittlin, S.	2018	Recent trends in malaria research	Division of Medicinal Chemistry

Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	Author	Year	Title	Publisher
4665554	Imlay, L. S.; Lawong, A. K.; Gahalawat, S.; Kumar, A.; Xing, C.; Mittal, N.; Wittlin, S.; Churchyard, A.; Niederstrasser, H.; Crespo-Fernandez, B.; Posner, B. A.; Gamo, F. J.; Baum, J.; Winzeler, E. A.; Laleu, B.; Ready, J. M.; Phillips, M. A.	2023	Fast-killing tyrosine amide ((S)-SW228703) with blood- and liver-stage antimalarial activity associated with the cyclic amine resistance locus (PfCARL)	ACS Infect Dis
4700018	Davies, H.; Bergmann, B.; Walloch, P.; Nerlich, C.; Hansen, C.; Wittlin, S.; Spielmann, T.; Treeck, M.; Beitz, E.	2023	The plasmodium lactate/H+ transporter PfFNT is essential and druggable in vivo	Antimicrob Agents Chemother
4665573	Nguyen, W.; Dans, M. G.; Currie, I.; Awalt, J. K.; Bailey, B. L.; Lumb, C.; Ngo, A.; Favuzza, P.; Palandri, J.; Ramesh, S.; Penington, J.; Jarman, K. E.; Mukherjee, P.; Chakraborty, A.; Maier, A. G.; van Dooren, G. G.; Papenfuss, T.; Wittlin, S.; Churchyard, A.; Baum, J.; Winzeler, E. A.; Baud, D.; Brand, S.; Jackson, P. F.; Cowman, A. F.; Sleebs, B. E.	2023	7-N-substituted-3-oxadiazole quinolones with potent antimalarial activity target the cytochrome bc1 complex	ACS Infect Dis
4665602	Walz, A.; Duffey, M.; Aljayyoussi, G.; Sax, S.; Leroy, D.; Besson, A.; Burrows, J. N.; Cherkaoui-Rbati, M. H.; Gobeau, N.; Westwood, M.-A.; Siethoff, C.; Gamo, S.; Mäser, P.; Wittlin, S.	2023	The Parasite Reduction Ratio (PRR) assay version 2: standardized assessment of Plasmodium falciparum viability after antimalarial treatment in vitro	Pharmaceuticals (Basel)
4651924	Xie, S. C.; Metcalfe, R. D.; Dunn, E.; Morton, C. J.; Huang, S. C.; Puhalovich, T.; Du, Y.; Wittlin, S.; Nie, S.; Luth, M. R.; Ma, L.; Kim, M. S.; Pasaje, C. F. A.; Kumpornsin, K.; Giannangelo, C.; Houghton, F. J.; Churchyard, A.; Famodimu, M. T.; Barry, D. C.; Gillett, D. L.; Dey, S.; Kosasih, C. C.; Newman, W.; Niles, J. C.; Lee, M. C. S.; Baum, J.; Ottilie, S.; Winzeler, E. A.; Creek, D. J.; Williamson, N.; Parker, M. W.; Brand, S.; Langston, S. P.; Dick, L. R.; Griffin, M. D. W.; Gould, A. E.; Tilley, L.	2022	Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy	Science
4651529	de Vries, L. E.; Jansen, P. A. M.; Barcelo, C.; Munro, J.; Verhoef, J. M. J.; Pasaje, C. F. A.; Rubiano, K.; Striepen, J.; Abla, N.; Berning, L.; Bolscher, J. M.; Demarta-Gatsi, C.; Henderson, R. W. M.; Huijs, T.; Koolen, K. M. J.; Tumwebaze, P. K.; Yeo, T.; Aguiar, A. C. C.; Angulo-Barturen, I.; Churchyard, A.; Baum, J.; Fernandez, B. C.; Fuchs, A.; Gamo, F. J.; Guido, R. V. C.; Jimenez-Diaz, M. B.; Pereira, D. B.; Rochford, R.; Roesch, C.; Sanz, L. M.; Trevitt, G.; Witkowski, B.; Wittlin, S.; Cooper, R. A.; Rosenthal, P. J.; Sauerwein, R. W.; Schalkwijk, J.; Hermkens, P. H. H.; Bonnert, R. V.; Campo, B.; Fidock, D. A.; Llinas, M.; Niles, J. C.; Kooij, T. W. A.; Dechering, K. J.	2022	Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183	Nat Commun
4657557	Mambwe, D.; Korkor, CM.; Mabhula, A.; Ngqumba, Z.; Cloete, C.; Kumar, M.; Barros, PL.; Leshabane, M.; Coertzen, D.; Taylor, D.; Gibhard, L.; Njoroge, M.; Lawrence, N.; Reader, J.; Moreira, DR.; Birkholtz, LM.; Wittlin, S.; Egan, TJ.; Chibale, K.	2022	Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and; in vivo; efficacy in a; Plasmodium berghei; mouse malaria infection model	Journal of medicinal chemistry
4651675	Laleu, B.; Rubiano, K.; Yeo, T.; Hallyburton, I.; Anderson, M.; Crespo-Fernandez, B.; Gamo, F. J.; Antonova-Koch, Y.; Orjuela-Sanchez, P.; Wittlin, S.; Jana, G. P.; Maity, B. C.; Chenu, E.; Duffy, J.; Sjo, P.; Waterson, D.; Winzeler, E.; Guantai, E.; Fidock, D. A.; Hansson, T.	2022	Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and the identification of its mode of resistance as PfeEF2	ChemMedChem
4651699	Lowe, M. A.; Cardenas, A.; Valentin, J. P.; Zhu, Z.; Abendroth, J.; Castro, J. L.; Class, R.; Delaunois, A.; Fleurance, R.; Gerets, H.; Gryshkova, V.; King, L.; Lorimer, D. D.; MacCoss, M.; Rowley, J. H.; Rosseels, M. L.; Royer, L.; Taylor, R. D.; Wong, M.; Zaccheo, O.; Chavan, V. P.; Ghule, G. A.; Tapkir, B. K.; Burrows, J. N.; Duffey, M.; Rottmann, M.; Wittlin, S.; Angulo-Barturen, I.; Jiménez-Díaz, M. B.; Striepen, J.; Fairhurst, K. J.; Yeo, T.; Fidock, D. A.; Cowman, A. F.; Favuzza, P.; Crespo-Fernandez, B.; Gamo, F. J.; Goldberg, D. E.; Soldati-Favre, D.; Laleu, B.; de Haro, T.	2022	Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of UCB7362	Journal of medicinal chemistry
4651547	Dong, Y.; Sonawane, Y.; Maher, S. P.; Zeeman, A. M.; Chaumeau, V.; Vantaux, A.; Cooper, C. A.; Chiu, F. C. K.; Ryan, E.; McLaren, J.; Chen, G.; Wittlin, S.; Witkowski, B.; Nosten, F.; Sriraghavan, K.; Kyle, D. E.; Kocken, C. H. M.; Charman, S. A.; Vennerstrom, J. L.	2022	Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12)	ACS Omega
4646325	Knaab, T. C.; Held, J.; Burckhardt, B. B.; Rubiano, K.; Okombo, J.; Yeo, T.; Mok, S.; Uhlemann, A. C.; Lungerich, B.; Fischli, C.; Pessanha de Carvalho, L.; Mordmüller, B.; Wittlin, S.; Fidock, D. A.; Kurz, T.	2021	3-Hydroxy-propanamidines, a new class of orally active antimalarials targeting Plasmodium falciparum	Journal of medicinal chemistry
4646305	Le Manach, C.; Dam, J.; Woodland, J. G.; Kaur, G.; Khonde, L. P.; Brunschwig, C.; Njoroge, M.; Wicht, K. J.; Horatscheck, A.; Paquet, T.; Boyle, G. A.; Gibhard, L.; Taylor, D.; Lawrence, N.; Yeo, T.; Mok, S.; Eastman, R. T.; Dorjsuren, D.; Talley, D. C.; Guo, H.; Simeonov, A.; Reader, J.; van der Watt, M.; Erlank, E.; Venter, N.; Zawada, J. W.; Aswat, A.; Nardini, L.; Coetzer, T. L.; Lauterbach, S. B.; Bezuidenhout, B. C.; Theron, A.; Mancama, D.; Koekemoer, L. L.; Birkholtz, L. M.; Wittlin, S.; Delves, M.; Ottilie, S.; Winzeler, E. A.; von Geldern, T. W.; Smith, D.; Fidock, D. A.; Street, L. J.; Basarab, G. S.; Duffy, J.; Chibale, K.	2021	Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite Plasmodium falciparum and optimization efforts	Journal of medicinal chemistry
4646430	Dziwornu, G. A.; Coertzen, D.; Leshabane, M.; Korkor, C. M.; Cloete, C. K.; Njoroge, M.; Gibhard, L.; Lawrence, N.; Reader, J.; van der Watt, M.; Wittlin, S.; Birkholtz, L. M.; Chibale, K.	2021	Antimalarial benzimidazole derivatives incorporating phenolic mannich base side chains inhibit microtubule and hemozoin formation: structure-activity relationship and in vivo oral efficacy studies	Journal of medicinal chemistry
4646308	Laleu, B.; Akao, Y.; Ochida, A.; Duffy, S.; Lucantoni, L.; Shackleford, D. M.; Chen, G.; Katneni, K.; Chiu, F. C. K.; White, K. L.; Chen, X.; Sturm, A.; Dechering, K. J.; Crespo, B.; Sanz, L. M.; Wang, B.; Wittlin, S.; Charman, S. A.; Avery, V. M.; Cho, N.; Kamaura, M.	2021	Discovery and structure-activity relationships of quinazolinone-2-carboxamide derivatives as novel orally efficacious antimalarials	Journal of medicinal chemistry
4646371	Hitz, E.; Grüninger, O.; Passecker, A.; Wyss, M.; Scheurer, C.; Wittlin, S.; Beck, H. P.; Brancucci, N. M. B.; Voss, T. S.	2021	The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis	Commun Biol
4646370	Hitz, E.; Wiedemar, N.; Passecker, A.; Graça, B. A. S.; Scheurer, C.; Wittlin, S.; Brancucci, N. M. B.; Vakonakis, I.; Mäser, P.; Voss, T. S.	2021	The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites	PLoS Biol
4646183	Palmer, M. J.; Deng, X.; Watts, S.; Krilov, G.; Gerasyuto, A.; Kokkonda, S.; El Mazouni, F.; White, J.; White, K. L.; Striepen, J.; Bath, J.; Schindler, K. A.; Yeo, T.; Shackleford, D. M.; Mok, S.; Deni, I.; Lawong, A.; Huang, A.; Chen, G.; Wang, W.; Jayaseelan, J.; Katneni, K.; Patil, R.; Saunders, J.; Shahi, S. P.; Chittimalla, R.; Angulo-Barturen, I.; Jimenez-Diaz, M. B.; Wittlin, S.; Tumwebaze, P. K.; Rosenthal, P. J.; Cooper, R. A.; Aguiar, A. C. C.; Guido, R. V. C.; Pereira, D. B.; Mittal, N.; Winzeler, E. A.; Tomchick, D. R.; Laleu, B.; Burrows, J. N.; Rathod, P. K.; Fidock, D. A.; Charman, S. A.; Phillips, M. A.	2021	Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate dehydrogenase inhibitor series	Journal of medicinal chemistry
4646306	Lawong, A.; Gahalawat, S.; Okombo, J.; Striepen, J.; Yeo, T.; Mok, S.; Deni, I.; Bridgford, J. L.; Niederstrasser, H.; Zhou, A.; Posner, B.; Wittlin, S.; Gamo, F. J.; Crespo, B.; Churchyard, A.; Baum, J.; Mittal, N.; Winzeler, E.; Laleu, B.; Palmer, M. J.; Charman, S. A.; Fidock, D. A.; Ready, J. M.; Phillips, M. A.	2021	Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in Plasmodium falciparum	Journal of medicinal chemistry
4646114	Shackleford, D. M.; Chiu, F. C. K.; Katneni, K.; Blundell, S.; McLaren, J.; Wang, X.; Zhou, L.; Sriraghavan, K.; Alker, A. M.; Hunziker, D.; Scheurer, C.; Zhao, Q.; Dong, Y.; Mohrle, J. J.; Abla, N.; Matile, H.; Wittlin, S.; Vennerstrom, J. L.; Charman, S. A.	2021	Cytochrome P450-mediated metabolism and CYP Inhibition for the synthetic peroxide antimalarial OZ439	ACS Infect Dis

Showing records 1 - 20 (of 139)