Randomized trial to test the efficacy of two interventions designed to increase screening and use of genetic services in young breast cancer survivors and biological female relatives
Project funded by own resources
Project title Randomized trial to test the efficacy of two interventions designed to increase screening and use of genetic services in young breast cancer survivors and biological female relatives
Principal Investigator(s) Katapodi, Maria
Co-Investigator(s) Duquette, Debra
Northouse, Laurel L
Janz, Nancy K
Merajver, Sofia D
Duffy, Sofia D
Jones, Tarsha
Project Members Ming, Chang
Anderson, Beth
Copeland, Glenn
Mendelsohn-Victor, Kari E
Milliron, Kara
Nikolaidis, Christos
Organisation / Research unit Departement Public Health / Pflegewissenschaft (Katapodi)
Project start 01.10.2011
Probable end 31.12.2020
Status Active
Abstract

Hintergrund: Over the past decades, advances in screening, detection, and treatment have led to a significant reduction in the number of breast cancer deaths in the United States. More specifically, Michigan had a 40% decrease in mortality rates between 1990 (11.9 per 100,000) and 2009 (7.1 per 100,000) among young women diagnosed with breast cancer. However, the Comprehensive Cancer Control Plan for Michigan and the Healthy People 2020 objective is to further “reduce the female breast cancer death rate”. The study strives to accomplish this goal, specifically for female breast cancer survivors diagnosed at 25-45 years old and their female relatives who may also have an increased risk.

Zielsetzung: The study has three aims: (1) To identify and survey 3000 female breast cancer survivors reported to the Michigan Cancer Surveillance Program who were diagnosed between the ages of 25-45 years (YBCS) and determine:(a) their breast cancer screening utilization; (b) perceived barriers and facilitators to screening; (c) willingness to participate in a small media, evidence-based intervention to increase breast cancer screening utilization; and (d) willingness to serve as a breast cancer screening advocate for their high-risk female relatives. (2) To identify and survey up to two unaffected first- and/or second- degree female relatives per breast cancer survivor and determine: (a) their breast cancer screening utilization; (b) perceived barriers and facilitators to screening; and (c) willingness to participate in a small media, evidence-based intervention to increase breast cancer screening utilization. (3) To compare the efficacy of two interventions on breast cancer screening utilization and other outcomes among YBCS and their high-risk female relatives.

Design / Methode: This prospective randomized trial involved testing the efficacy of two printed interventions i.e., Targeted vs. Enhanced Tailored designed to increase screening and use of cancer genetic services. Participants were randomly assigned as family units (YBCS and her female relatives) to receive one of two intervention versions. Family units were mailed a self-administered baseline survey prior to receiving the intervention (Time 1). A self-administered follow-up survey was mailed to participants nine months post-intervention.

Erwarteter Nutzen / Relevanz (z.B. für Public Health): The study enhanced cancer prevention, control, and efforts toward public health genomics interventions. The two intervention versions provide a successful platform for implemention of public health genomic interventions.

Keywords public health genomics, family-based, statewide, random sampling, random allocation
Financed by Other funds

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
3977272  Katapodi, M. C.; Northouse, L. L.; Schafenacker, A. M.; Duffy, S. A.; Ronis, D. L.; Anderson, B.; Janz, N. K.; McLosky, J.; Milliron, K. J.; Merajver, S. D.; Duong, L. M.; Copeland, G.  Using a state cancer registry to recruit young breast cancer survivors and high-risk relatives: protocol of a randomized trial testing the efficacy of a targeted versus a tailored intervention to increast breast cancer screening  1471-2407  BMC Cancer  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3966373  Jones, Tarsha; Lockhart, Joan S.; Mendelsohn-Victor, Kari E.; Duquette, Debra; Northouse, Laurel L.; Duffy, Sonia A.; Donley, Rosemary; Merajver, Sofia D.; Milliron, Kara J.; Roberts, J. Scott; Katapodi, Maria C.  Use of Cancer Genetics Services in African-American Young Breast Cancer Survivors  0749-3797 ; 1873-2607  American journal of preventive medicine  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
3969246  Katapodi, Maria C; Duquette, Debra; Yang, James J; Mendelsohn-Victor, Kari E; Anderson, Beth; Nikolaidis, Christos; Mancewicz, Emily; Northouse, Laurel L; Duffy, Sonia A; Ronis, David; Milliron, Kara J; Probst-Hensch, Nicole; Merajver, Sofia D; Janz, Nancy K; Copeland, Glenn; Roberts J Scott  Recruiting families at risk for hereditary breast and ovarian cancer from a statewide cancer registry: a methodological study.    Cancer Causes and Control  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 

Cooperations ()

  ID Kreditinhaber Kooperationspartner Institution Laufzeit - von Laufzeit - bis
3978008  Katapodi, Maria  Duquette, Debra, Clinical Prof.  Northwestern University, Feinberg School of Medicine  01.10.2011  31.12.2020 
3978015  Katapodi, Maria  Northouse, Laurel, Prof. Dr.  University of Michigan School of Nursing  01.10.2011  31.12.2020 
3978020  Katapodi, Maria  Janz, Nancy K, Prof. Dr.  University of Michigan School of Public Health  01.10.2011  31.12.2020 
3978022  Katapodi, Maria  Merajver, Sofia D, Prof. Dr.  University of Michigan School of Medicine  01.10.2011  31.12.2020 
3978026  Katapodi, Maria  Duffy, Sonia, A Prof. Dr.  Ohio State University, College of Nursing  01.10.2011  31.12.2021 
   

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