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Aminoglykoside bei Patienten mit Mukoviszidose und pulmonaler Exazerbation : Vergleich von Einmal- und Dreimalgabe
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 97539
Author(s) Heininger, U; Böwing, B; Stehr, K; Solbach, W
Author(s) at UniBasel Heininger, Ulrich
Year 1993
Title Aminoglykoside bei Patienten mit Mukoviszidose und pulmonaler Exazerbation : Vergleich von Einmal- und Dreimalgabe
Journal Klinische Pädiatrie
Volume 205
Number 1
Pages / Article-Number 18-22
Abstract

Twenty-six patients with cystic fibrosis and pulmonary exacerbations were enrolled in a prospective randomized study to compare the efficacy of aminoglycosides (tobramycin or netilmicin) administered once daily (21 episodes, 5 with netilmicin, 16 with tobramycin) and thrice daily (23 episodes, 2 with netilmicin, 21 with tobramycin), respectively. In addition, the patients received an anti-pseudomonal beta-lactam antibiotic. In the single-dose group the total daily dosage was 4.97 +/- 1.12 mg/kg (total dosage per exacerbation: 74.55 mg/kg), compared to 9.60 +/- 2.70 mg/kg in the triple-dose group (total dosage per exacerbation: 165.12 mg/kg). The mean peak and trough serum levels of the aminoglycoside were 8.31 +/- 1.76 mg/l and 0.18 +/- 0.10 mg/l, respectively in the single dose group compared to 6.12 +/- 1.30 mg/l and 0.58 +/- 0.31 mg/l in the triple dose group. Success of treatment, defined as decrease in leucocyte counts, normalization of elevated CRP-values, number of days in hospital and interval until next admission to hospital, was not different between both groups. We conclude that single daily dose of aminoglycosides was as efficacious as triple dose in our patients.

Publisher Enke
ISSN/ISBN 0300-8630
edoc-URL http://edoc.unibas.ch/dok/A5839217
Full Text on edoc No
Digital Object Identifier DOI 10.1055/s-2007-1025191
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8445848
ISI-Number WOS:A1993KM34500005
Document type (ISI) Clinical Trial, Journal Article, Randomized Controlled Trial
Additional Information Note: Engl. Übersetzung des Titels: Aminoglycosides in patients with mucoviscidosis and pulmonary exacerbation. Comparison of once or three times daily administration
 
   

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