Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
A comparative efficacy trial in Germany in infants who received either the Lederle/Takeda acellular pertussis component DTP (DTaP) vaccine, the Lederle whole-cell component DTP vaccine, or DT vaccine
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 97522
Author(s) Christenson, P.
Author(s) at UniBasel Heininger, Ulrich
Year 1998
Title A comparative efficacy trial in Germany in infants who received either the Lederle/Takeda acellular pertussis component DTP (DTaP) vaccine, the Lederle whole-cell component DTP vaccine, or DT vaccine
Journal Pediatrics
Volume 101
Number 1 Pt 1
Pages / Article-Number 1-11
Abstract BACKGROUND. The goal of the trial was to determine the efficacy of a multicomponent acellular pertussis vaccine against Bordetella illnesses in comparison with a whole-cell product and DT. DESIGN. In a randomized, double-blind fashion, 2- to 4-month-old infants received 4 doses of either DTP or DTaP vaccine at 3, 4.5, 6, and 15 to 18 months of age. The controls received 3 doses (3, 4.5, 15 to 18 months of age) of DT vaccine. The DTP vaccine was Lederle adsorbed vaccine (licensed in the United States) and DTaP was Lederle/Takeda adsorbed vaccine. Follow-up for vaccine efficacy started 2 weeks after the third dose (DTP/DTaP) and at the same age (6.5 months) in DT recipients. Reactogenicity of all doses of all three vaccines was documented by standardized parent diary cards. In addition, all subjects were monitored for respiratory illnesses and serious adverse events by biweekly phone calls. RESULTS. From May 1991 to January 1993, a total of 10 271 infants were enrolled: 8532 received either DTP or DTaP and 1739 received DT. Specific efficacy against B pertussis infections with cough
Publisher American Academy of Pediatrics
ISSN/ISBN 0031-4005
edoc-URL http://edoc.unibas.ch/dok/A5839201
Full Text on edoc No
Digital Object Identifier DOI 10.1542/peds.101.1.1
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/9417143
ISI-Number WOS:000071331400001
Document type (ISI) Clinical Trial, Journal Article, Randomized Controlled Trial
 
   

MCSS v5.8 PRO. 0.334 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024