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Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorder
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 969514
Author(s) de Quervain, Dominique J.-F.
Author(s) at UniBasel de Quervain, Dominique
Year 2006
Title Glucocorticoid-induced inhibition of memory retrieval: implications for posttraumatic stress disorder
Journal Annals of the New York Academy of Sciences
Volume 1071
Pages / Article-Number 216-220
Abstract Posttraumatic stress disorder (PTSD) is characterized by traumatic memories that can manifest as daytime recollections, traumatic nightmares, or flashbacks in which components of the event are relieved. These symptoms reflect excessive retrieval of traumatic memories that often retain their vividness and power to evoke distress for decades or even a lifetime. We have reported previously that elevated glucocorticoid levels inhibit memory retrieval in animals and healthy human subjects. We therefore hypothesized that the administration of cortisol might also inhibit the retrieval of traumatic memories in patients with PTSD. In a recent pilot study, we found the first evidence to support this hypothesis. During a 3-month observation period, low-dose cortisol (10 mg/day) was administered orally for 1 month to three patients with chronic PTSD using a double-blind, placebo-controlled, crossover design. In each patient investigated, there was a significant treatment effect with cortisol-related reductions in one of the daily rated symptoms of traumatic memories without causing adverse side effects. Future studies with more patients and longer treatment periods are required to evaluate the efficacy of cortisol treatment for PTSD.
Publisher Wiley
ISSN/ISBN 0077-8923 ; 1749-6632
edoc-URL http://edoc.unibas.ch/46523/
Full Text on edoc No
Digital Object Identifier DOI 10.1196/annals.1364.016
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/16891572
ISI-Number WOS:000240653600016
Document type (ISI) ArticleProceedings Paper
 
   

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