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Anticipatory cognitive stress appraisal and the acute procoagulant stress response in men
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 961762
Author(s) Wirtz, Petra H.; Ehlert, Ulrike; Emini, Luljeta; Rüdisüli, Katharina; Groessbauer, Sara; Gaab, Jens; Elsenbruch, Sigrid; von Känel, Roland
Author(s) at UniBasel Gaab, Jens
Year 2006
Title Anticipatory cognitive stress appraisal and the acute procoagulant stress response in men
Journal Psychosomatic Medicine
Volume 68
Number 6
Pages / Article-Number 851-8
Abstract Acute mental stress elicits blood hypercoagulability. Following a transactional stress model, we investigated whether individuals who anticipate stress as more threatening, challenging, and as exceeding their coping skills show greater stress reactivity of the coagulation activation marker D-dimer, indicating fibrin generation in plasma.; Forty-seven men (mean age 44 +/- 14 years; mean blood pressure [MBP] 101 +/- 12 mm Hg; mean body mass index [BMI] 26 +/- 3 kg/m(2)) completed the Primary Appraisal Secondary Appraisal (PASA) scale before undergoing the Trier Social Stress Test (combination of mock job interview and mental arithmetic task). Heart rate, blood pressure, plasma catecholamines, and D-dimer levels were measured before and after stress, and during recovery up to 60 minutes poststress.; Hemodynamic measures, catecholamines, and D-dimer changed across all time points (p values <.001). The PASA "Stress Index" (integrated measure of transactional stress perception) correlated with total D-dimer area under the curve (AUC) between rest and 60 minutes poststress (r = 0.30, p = .050) and with D-dimer change from rest to immediately poststress (r = 0.29, p = .046). Primary appraisal (combined "threat" and "challenge") correlated with total D-dimer AUC (r = 0.37, p = .017), D-dimer stress change (r = 0.41, p = .004), and D-dimer recovery (r = 0.32, p = .042). "Challenge" correlated more strongly with D-dimer stress change than "threat" (p = .020). Primary appraisal (DeltaR(2) = 0.098, beta = 0.37, p = .019), and particularly its subscale "challenge" (DeltaR(2) = 0.138, beta = 0.40, p = .005), predicted D-dimer stress change independently of age, BP, BMI, and catecholamine change.; Anticipatory cognitive appraisal determined the extent of coagulation activation to and recovery from stress in men. Particularly individuals who anticipated the stressor as more challenging and also more threatening had a greater fibrin stress response.
Publisher Lippincott Williams & Wilkins
ISSN/ISBN 0033-3174 ; 1534-7796
edoc-URL http://edoc.unibas.ch/46391/
Full Text on edoc No
Digital Object Identifier DOI 10.1097/01.psy.0000245866.03456.aa
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/17132836
ISI-Number WOS:000242259300006
Document type (ISI) Journal Article
 
   

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