A spindle-independent cleavage furrow positioning pathway

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A spindle-independent cleavage furrow positioning pathway

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	870382
Author(s)	Cabernard, Clemens; Prehoda, Kenneth E.; Doe, Chris Q.
Author(s) at UniBasel	Cabernard, Clemens
Year	2010
Title	A spindle-independent cleavage furrow positioning pathway
Journal	Nature
Volume	467
Number	7311
Pages / Article-Number	91-U124
Abstract	The mitotic spindle determines the cleavage furrow site during metazoan cell division, but whether other mechanisms exist remains unknown. Here we identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts. We show that early and late furrow proteins (Pavarotti, Anillin, and Myosin) are localized to the neuroblast basal cortex at anaphase onset by a Pins cortical polarity pathway, and can induce a basally displaced furrow even in the complete absence of a mitotic spindle. Rotation or displacement of the spindle results in two furrows: an early polarity-induced basal furrow and a later spindle-induced furrow. This spindle-independent cleavage furrow mechanism may be relevant to other highly polarized mitotic cells, such as mammalian neural progenitors.
Publisher	Macmillan
ISSN/ISBN	0028-0836 ; 1476-4687
edoc-URL	http://edoc.unibas.ch/46104/
Full Text on edoc	No
Digital Object Identifier DOI	10.1038/nature09334
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/20811457
ISI-Number	WOS:000281461200041
Document type (ISI)	Article

20/04/2024

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