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Anteroposterior regionalization of the brain : genetic and comparative aspects
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 84595
Author(s) Lichtneckert, Robert; Reichert, Heinrich
Author(s) at UniBasel Reichert, Heinrich
Year 2008
Title Anteroposterior regionalization of the brain : genetic and comparative aspects
Journal Advances in experimental medicine and biology
Volume 628
Pages / Article-Number 32-41
Abstract Developmental genetic analyses of embryonic CNS development in Drosophila have uncovered the role of key, high-order developmental control genes in anteroposterior regionalization of the brain. The gene families that have been characterized include the otd/Otx and ems/Emx genes which are involved in specification of the anterior brain, the Hox genes which are involved in the differentiation of the posterior brain and the Pax genes which are involved in the development of the anterior/posterior brain boundary zone. Taken together with work on the genetic control of mammalian CNS development, these findings indicate that all three gene sets have evolutionarily conserved roles in brain development, revealing a surprising evolutionary conservation in the molecular mechanisms of brain regionalization.
Publisher SPRINGER-VERLAG BERLIN
ISSN/ISBN 0065-2598
edoc-URL http://edoc.unibas.ch/dok/A5250923
Full Text on edoc No
Digital Object Identifier DOI 10.1007/978-0-387-78261-4_2
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18683636
ISI-Number WOS:000254980600002
Document type (ISI) Journal Article, Review
Additional Information Also published in: Brain development in "Drosophila melanogaster". - New York : Springer, 2008. - S. 32-41
 
   

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