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Bace2 Is a Beta-Cell-Enriched Protease that Regulates Pancreatic Beta-Cell Function and Mass
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 832485
Author(s) Esterházy, Daria; Stützer, Ina; Wang, Haiyan; Rechsteiner, Markus P.; Beauchamp, Jeremy; Döbeli, Heinz; Hilpert, Hans; Matile, Hugues; Prummer, Michael; Schmidt, Alexander; Lieske, Nora; Boehm, Bernhard; Marselli, Lorella; Bosco, Domenico; Kerr-Conte, Julie; Aebersold, Ruedi; Spinas, Giatgen Andreia; Moch, Holger; Migliorini, Cristiano; Stoffel, Markus
Author(s) at UniBasel Schmidt, Alexander
Year 2011
Title Bace2 Is a Beta-Cell-Enriched Protease that Regulates Pancreatic Beta-Cell Function and Mass
Journal Cell Metabolism
Volume 14
Number 3
Pages / Article-Number 365-77
Abstract Decreased ? cell mass and function are hallmarks of type 2 diabetes. Here we identified, through a siRNA screen, beta site amyloid precursor protein cleaving enzyme 2 (Bace2) as the sheddase of the proproliferative plasma membrane protein Tmem27 in murine and human ? cells. Mice with functionally inactive Bace2 and insulin-resistant mice treated with a newly identified Bace2 inhibitor both display augmented ? cell mass and improved control of glucose homeostasis due to increased insulin levels. These results implicate Bace2 in the control of ? cell maintenance and provide a rational strategy to inhibit this protease for the expansion of functional pancreatic ? cell mass.
Publisher Cell Press
ISSN/ISBN 1550-4131 ; 1932-7420
edoc-URL http://edoc.unibas.ch/46063/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.cmet.2011.06.018
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21907142
ISI-Number WOS:000295660200011
Document type (ISI) Journal Article
 
   

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