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Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 79682
Author(s) Faraone, Stephen V.
Author(s) at UniBasel Steinhausen, Hans-Christoph
Year 2008
Title Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings
Journal Biological psychiatry
Volume 64
Number 7
Pages / Article-Number 571-6
Keywords ADHD, linkage, QTL
Abstract BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p > .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.
Publisher Elsevier
ISSN/ISBN 0006-3223
edoc-URL http://edoc.unibas.ch/dok/A5250682
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.biopsych.2008.02.024
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18439570
ISI-Number WOS:000259588600004
Document type (ISI) Journal Article
 
   

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