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TOR complexes: composition, structure and phosphorylation
Editor(s)
Hall, M.N.; Tamanoi, F.
Book title
Structure, function and regulation of TOR complexes from yeasts to mammals
Volume
27
Publisher
Elsevier
Place of publication
Amsterdam
Pages
1-20
ISSN/ISBN
978-0-12-381539-2
Series title
Enzymes
Number
Part A
Abstract
The target of rapamycin (TOR) is the central node of a highly conserved signaling network that regulates cell growth in response to nutrients, growth factors, and cellular energy. TOR is found in two functionally distinct complexes, TOR complex 1 (TORC1) and TORC2. This chapter describes the composition of yeast and mammalian TOR complexes, with special focus on the roles of structural domains and phosphorylation in TOR complex function.
