Deficits in adherence to treatment plan in schizophrenia in spite of availability of atypicals with lower rate of side effects persist as a severe risk for long term course of schizophrenia. Maladherence is the main reason for the gap between effectivity of treatment and poor outcome in schizophrenia. Data concerning prevalence of malcompliance and its' preceding variables as well as theoretical frameworks are discussed. Main intervention strategies and their efficacy are reported.