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Trematocidal synthetic peroxides
| Third-party funded project |
| Project title |
Trematocidal synthetic peroxides |
| Principal Investigator(s) |
Vennerstrom, Jonathan
Keiser, Jennifer
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| Organisation / Research unit |
Swiss Tropical and Public Health Institute (Swiss TPH) / Helminth Drug Development (Keiser) |
| Project start |
15.07.2008 |
| Probable end |
30.06.2010 |
| Status |
Completed |
| Abstract |
Food-borne trematodiases affect hundreds of millions of people, particularly the rural poor in the developing world. Since vaccines are currently unavailable, and are unlikely to become available anytime soon for the prevention of food-borne tremotodiases, effective drugs are the only practical means of morbidity control. Importantly, new drugs for these diseases are urgently needed as praziquantel and triclabendazole are the only drugs available and the development of resistance cannot be ignored, particularly in view of the large-scale use of praziquantel in many endemic countries. At the root of this project is our discovery that several synthetic peroxides – namely 1,2,4-trioxolane or secondary ozonide (OZ) carboxylic acids – also possess strong trematocidal activity. Preliminary testing with OZ78 revealed significant activity against the food-borne trematodes Fasciola hepatica and Clonorchis sinensis. The overarching objective of this proposal is to further explore the potential of 1,2,4-trioxolane carboxylic acids and related synthetic peroxides as novel trematocidal drugs. |
| Financed by |
Foreign Governmental Research Agencies
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29/04/2024
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