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Assessment of varicella vaccine effectiveness in Germany: a time-series approach
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 675558
Author(s) Höhle, M.; Siedler, A.; Bader, H.-M.; Ludwig, M.; Heininger, U.; V. O. N. Kries, R.
Author(s) at UniBasel Heininger, Ulrich
Year 2011
Title Assessment of varicella vaccine effectiveness in Germany: a time-series approach
Journal Epidemiology and Infection
Volume 139
Number 11
Pages / Article-Number 1710-9
Keywords GP surveillance systems, infectious disease epidemiology, statistics, vaccines, varicella zoster
Mesh terms Chickenpox, prevention & control; Chickenpox Vaccine, immunology; Child; Child, Preschool; Cohort Studies; General Practitioners; Germany, epidemiology; Humans; Immunity, Herd; Immunization Schedule; Infant; Multivariate Analysis; Sentinel Surveillance
Abstract A multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.
Publisher Cambridge University Press
ISSN/ISBN 0950-2688 ; 1469-4409
edoc-URL http://edoc.unibas.ch/dok/A5843711
Full Text on edoc No
Digital Object Identifier DOI 10.1017/S0950268810002815
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21156098
Document type (ISI) Journal Article
Additional Information Note: First published online 15 December 2010.
 
   

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