A novel tool for the prediction of tablet sticking during high speed compaction
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 673064
Author(s) Abdel-Hamid, Sameh; Betz, Gabriele
Author(s) at UniBasel Betz, Gabriele
Year 2012
Title A novel tool for the prediction of tablet sticking during high speed compaction
Journal Pharmaceutical development and technology
Volume 17
Number 6
Pages / Article-Number 747-54
Keywords Sticking, adhesion, radial die-wall pressure, Mefenamic acid, compaction simulation
Abstract

During tableting, capping is a problem of cohesion while sticking is a problem of adhesion. Sticking is a multi-composite problem; causes are either material or machine related. Nowadays, detecting such a problem is a pre-requisite in the early stages of development. The aim of our study was to investigate sticking by radial die-wall pressure monitoring guided by compaction simulation. This was done by using the highly sticking drug; Mefenamic acid (MA) at different drug loadings with different fillers compacted at different pressures and speeds. By increasing MA loading, we found that viscoelastic fillers showed high residual radial pressure after compaction while plastic/brittle fillers showed high radial pressure during compaction, p?

Publisher Marcel Dekker
ISSN/ISBN 1083-7450
edoc-URL http://edoc.unibas.ch/dok/A5843685
Full Text on edoc No
Digital Object Identifier DOI 10.3109/10837450.2011.580761
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21563986
ISI-Number WOS:000311897000013
Document type (ISI) Article
Additional Information Note: Online publiziert am 13.5.2011
 
   

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