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Tumor-specific expression of therapeutic molecules by tumorcolonizing bacteria
Third-party funded project |
Project title |
Tumor-specific expression of therapeutic molecules by tumorcolonizing bacteria |
Principal Investigator(s) |
Bumann, Dirk
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Organisation / Research unit |
Departement Biozentrum / Molecular Microbiology (Bumann) |
Project start |
01.02.2008 |
Probable end |
31.01.2011 |
Status |
Completed |
Abstract |
Salmonella genes that are expressed in normal tissues are compared with expression patterns in tumor tissues. Candidate promoters are validated using reporter gene fusions and in vivo analysis with flow cytometry. Suitable promoters are then used to drive pro-drug converting enzyme expression in tumor-targeting Salmonella. |
Keywords |
Infection biology, metabolism, systems biology, typhoid fever, flow cytometry |
Financed by |
Foreign Governmental Research Agencies
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26/04/2024
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