Centrosome aberrations : cause or consequence of cancer progression?

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Centrosome aberrations : cause or consequence of cancer progression?

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	59344
Author(s)	Nigg, Erich A
Author(s) at UniBasel	Nigg, Erich
Year	2002
Title	Centrosome aberrations : cause or consequence of cancer progression?
Journal	Nature reviews. Cancer
Volume	2
Number	11
Pages / Article-Number	815-25
Abstract	Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression?.
Publisher	Nature Publishing Group
ISSN/ISBN	1474-175X
edoc-URL	http://edoc.unibas.ch/dok/A5249400
Full Text on edoc	No
Digital Object Identifier DOI	10.1038/nrc924
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/12415252
ISI-Number	WOS:000180448200012
Document type (ISI)	Journal Article, Review

02/05/2024

Research Database / FORSCHUNGSDATENBANK