Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 57922
Author(s) Christen, Verena; Treves, Susan; Duong, Francois H. T.; Heim, Markus H.
Author(s) at UniBasel Treves, Susan
Year 2007
Title Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A
Journal Hepatology
Volume 46
Number 2
Pages / Article-Number 558-65
Abstract The up-regulation of protein phosphatase 2 A (PP2A) is an important factor leading to an inhibition of IFNalpha signaling caused by viral protein expression. Here, we describe the molecular mechanism involved in PP2Ac up-regulation by HCV and HBV. HCV and HBV protein expression in cells induces an ER stress response leading to calcium release from the ER. HCV protein expression induces CREB activation, probably through calcium/calmodulin-dependent protein kinase. CREB binds to a CRE element in the promoter of PP2Ac and induces its transcriptional up-regulation. Because PP2Ac is involved in many important cellular processes including cell-cycle regulation, apoptosis, cell morphology, development, signal transduction and translation, its up-regulation during ER stress has potentially important implications.
Publisher Wiley
ISSN/ISBN 0270-9139 ; 1527-3350
edoc-URL http://edoc.unibas.ch/dok/A6174310
Full Text on edoc Restricted
Digital Object Identifier DOI 10.1002/hep.21611
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/17526027
ISI-Number WOS:000248501600034
Document type (ISI) Journal Article
 
   

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