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Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 533215
Author(s) Malebo, H M; Tanja, W; Cal, M; Swaleh, S A M; Omolo, M O; Hassanali, A; Séquin, U; Hamburger, M; Brun, R; Ndiege, I O
Author(s) at UniBasel Brun, Reto
Wenzler, Tanja
Year 2009
Title Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants
Journal Tanzania journal of health research
Volume 11
Number 4
Pages / Article-Number 226-34
Abstract The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae), Drypetes natalensis (Euphorbiaceae), Acridocarpus chloropterus (Malpighiaceae), Maytenus senegalensis (Celastraceae) and Neurautanenia mitis (Papilonaceae), were evaluated in vitro against Plasmodium falciparum K1, Trypanosoma brucei rhodesiense STIB 900 and axenic Leishmania donovani MHOM-ET-67/82. Out of the 25 extracts tested, 17 showed good antiplasmodial activity (IC50 0.04-5.0 microg/ml), 7 exhibited moderate anti-trypanosomal activity (IC50 2.3-2.8 microg/ml), while 5 displayed mild anti-leishmanial activity (IC50 8.8-9.79 microg/ml). A. kummeriae, A. annua, P. microcarpa, D. natalensis, M. senegalensis and N. mitis extracts had good antiplasmodial activity (IC50 0.04-2.1 microg/ml) and selectivity indices (29.2-2,250 microg/ml). The high antiplasmodial, moderate anti-trypanosomal and mild anti-leishmanial activity make these plants good candidates for bioassay-guided isolation of anti-protozoal compounds which could serve as new lead structures for drug development
Publisher HRUTF
edoc-URL http://edoc.unibas.ch/dok/A5843143
Full Text on edoc No
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20734703
ISI-Number MEDLINE:20734703
Document type (ISI) Journal Article
 
   

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