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Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 524730
Author(s) Faist, J.; Seebacher, W.; Kaiser, M.; Brun, R.; Saf, R.; Weis, R.
Author(s) at UniBasel Brun, Reto
Kaiser, Marcel
Year 2010
Title Alkyl and dialkylaminoethyl derivatives of 5-amino-2-azabicyclo[3.2.2]nonanes and their antiplasmodial and antitrypanosomal activities
Journal European Journal of Medicinal Chemistry
Volume 45
Number 1
Pages / Article-Number 179-185
Abstract N-Alkyl and N-(2-dialkylaminoethyl) derivatives of 5-amino-2-azabicyclo-nonanes were prepared and tested in vitro for their activities against the multidrug-resistant K1 strain of Plasmodium falciparum and Trypanosoma brucei rhodesiense (STIB 900). Most of the new compounds showed lower antitrypanosomal activity than their parent compounds. With respect to their activity against P. falciparum the N-alkyl derivatives exhibited worse selectivity due to decreased antiplasmodial activity or higher cytotoxicity. In comparison all of the new N-(2-dialkylaminoethyl) analogues possessed a much better selectivity and a single of these compounds showed even better antiplasmodial activity and selectivity than chloroquine
Publisher EDIFOR
ISSN/ISBN 0223-5234
edoc-URL http://edoc.unibas.ch/dok/A5843075
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.ejmech.2009.09.040
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19879671
 
   

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