Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 524412
Author(s) Gachet, María Salomé; Lecaro, Javier Salazar; Kaiser, Marcel; Brun, Reto; Navarrete, Hugo; Muñoz, Ricardo A; Bauer, Rudolf; Schühly, Wolfgang
Author(s) at UniBasel Brun, Reto
Kaiser, Marcel
Year 2010
Title Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis
Journal Journal of ethnopharmacology : an interdisciplinary journal devoted to bioscientific research on indigenous drugs
Volume 128
Number 1
Pages / Article-Number 184-97
Keywords In vitro screening, Leishmaniasis, Traditional medicine, Malaria, Trypanosomiasis, Ecuadorian plants
Abstract AIM OF THE STUDY: For the assessment of the in vitro anti-protozoal potential of plants traditionally used in Ecuador in the treatment of leishmaniasis, a combined approach based on interviews with healers as well as a literature search was carried out. MATERIALS AND METHODS: From three regions of Ecuador, 256 local healers called 'Agents of Traditional Medicine' (ATMs) were interviewed about their knowledge of the use of plants to treat and heal the illness recognized by the ATMs as leishmaniasis. From literature sources, 14 plants were identified as being used in the treatment of leishmaniasis. Subsequently, plant material was collected from a representative selection of 39 species. A total of 140 extracts were screened in vitro against Leishmania donovani, Plasmodium falciparum, Trypanosoma brucei rhodesiense and Trypanosoma cruzi. Additionally, these extracts were evaluated for their anti-microbial activities using five gram-positive and -negative bacteria as well as Candida albicans. RESULTS AND CONCLUSIONS: The survey resulted in 431 use-records for 145 plant-taxa used for the treatment of leishmaniasis. The 10 most frequently reported taxa accounted for 37.7% of all records. In the case of leishmaniasis, activity was observed for Elephantopus mollis, Minquartia guianensis, Bocconia integrifolia, Gouania lupuloides, Scoparia dulcis, an as-yet-unidentified species of Piper and Brugmansia. For the leaves of M. guianensis and the twigs and bark of G. lupuloides a good selectivity index (SI) was found. IC(50) values and the SI of active plant extracts are presented
Publisher Elsevier Scientific Publishers
ISSN/ISBN 0378-8741
edoc-URL http://edoc.unibas.ch/dok/A5842824
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jep.2010.01.007
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20064594
ISI-Number WOS:000276010000025
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.438 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
08/08/2020