Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 524403
Author(s) Spavieri, Jasmine; Allmendinger, Andrea; Kaiser, Marcel; Casey, Rosalyn; Hingley-Wilson, Suzie; Lalvani, Ajit; Guiry, Michael D; Blunden, Gerald; Tasdemir, Deniz
Author(s) at UniBasel Kaiser, Marcel
Year 2010
Title Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters
Journal Phytotherapy research : an international journal devoted to pharmacological and toxocological evaluation of natural product derivatives
Volume 24
Number 11
Pages / Article-Number 1724-9
Keywords Brown algae, Phaeophyceae, Trypanosoma, Leishmania, Mycobacterium, cytotoxicity
Abstract In the continuation of our research on seaweeds, crude extracts of 21 brown algae collected from the south coast of England and the west coast of Ireland were screened for in vitro trypanocidal, leishmanicidal and antimycobacterial activities. Mammalian stages of a small set of parasitic protozoa; i.e. Trypanosoma brucei rhodesiense, T. cruzi and Leishmania donovani, and the tubercle bacillus Mycobacterium tuberculosis were used as test organisms. The extracts were also evaluated for selectivity by testing on a mammalian cell line (L6 cells). Only four extracts were moderately active against T. cruzi, whereas all algal extracts showed significant activity against T. brucei rhodesiense, with Halidrys siliquosa and Bifurcaria bifurcata (Sargassaceae) being the most potent (IC50 values 1.2 and 1.9 mug/mL). All algal extracts also displayed leishmanicidal activity, with H. siliquosa and B. bifurcata again being the most active (IC50s 6.4 and 8.6 mug/mL). When tested against M. tuberculosis, only the B. bifurcata extract was found to have some antitubercular potential (MIC value 64.0 mug/mL). Only three seaweed extracts, i.e. H. siliquosa, B. bifurcata and Cystoseira tamariscifolia showed some cytotoxicity. To our knowledge, this is the first study on the antiprotozoal and antimycobacterial activity of brown algae from British and Irish waters
Publisher John Wiley
ISSN/ISBN 1099-1573
edoc-URL http://edoc.unibas.ch/dok/A5842817
Full Text on edoc No
Digital Object Identifier DOI 10.1002/ptr.3208
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20564461
ISI-Number WOS:000283794300025
Document type (ISI) Journal Article
 
   

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