Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 524397
Author(s) Wright, Colin W; Linley, Peter A; Brun, Reto; Wittlin, Sergio; Hsu, Elisabeth
Author(s) at UniBasel Brun, Reto
Wittlin, Sergio
Year 2010
Title Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity
Journal Molecules
Volume 15
Number 2
Pages / Article-Number 804-12
Keywords chinese herbal texts, Artemisia annua, artemisinin, malaria
Abstract Ancient Chinese herbal texts as far back as the 4th Century Zhou hou bei ji fang describe methods for the use of Qing Hao (Artemisia annua) for the treatment of intermittent fevers. Today, the A. annua constituent artemisinin is an important antimalarial drug and the herb itself is being grown and used locally for malaria treatment although this practice is controversial. Here we show that the ancient Chinese methods that involved either soaking, (followed by wringing) or pounding, (followed by squeezing) the fresh herb are more effective in producing artemisinin-rich extracts than the usual current method of preparing herbal teas from the dried herb. The concentrations of artemisinin in the extracts was up to 20-fold higher than that in a herbal tea prepared from the dried herb, but the amount of total artemisinin extracted by the Chinese methods was much less than that removed in the herbal tea. While both extracts exhibited potent in vitro activities against Plasmodium falciparum, only the pounded juice contained sufficient artemisinin to suppress parasitaemia in P. berghei infected mice. The implications of these results are discussed in the context of malaria treatment using A. annua infusions
Publisher MDPI
ISSN/ISBN 1420-3049
edoc-URL http://edoc.unibas.ch/dok/A5842811
Full Text on edoc No
Digital Object Identifier DOI 10.3390/molecules15020804
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20335947
ISI-Number WOS:000274929200018
Document type (ISI) Article
 
   

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