Advances in metabolic profiling of experimental nematode and trematode infections
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 524384
Author(s) Wang, Yulan; Li, Jia V; Saric, Jasmina; Keiser, Jennifer; Wu, Junfang; Utzinger, Jürg; Holmes, Elaine
Author(s) at UniBasel Keiser, Jennifer
Utzinger, Jürg
Year 2010
Title Advances in metabolic profiling of experimental nematode and trematode infections
Journal Advances in parasitology
Volume 73
Pages / Article-Number 373-404
Abstract Metabonomics, which is the combination of metabolic profiling of biological samples using spectroscopic methods, together with multivariate data analysis, is a powerful approach for biomarker recovery. Moreover, metabonomics holds promise to enhance our understanding of host-parasite interactions at the metabolic level, and therefore provides a framework for discovery of novel targets for diagnostics, drugs and vaccines. In this review, we summarise progress made to date with metabolic profiling strategies applied to different host-parasite models in the laboratory. First, we emphasise the application of two parasitic worm infections that are particularly relevant for Southeast Asia and the People's Republic of China, namely the trematode Schistosoma japonicum causing schistosomiasis, and the nematode Necator americanus causing hookworm disease. Next, we review metabolic profiling studies on the liver fluke Fasciola hepatica in the rat model, the intestinal fluke Echinostoma caproni harboured in mice and characterise the metabolic responses in the hamster to a S. japonicum-N. americanus co-infection. We extract parasite-specific biomarkers and distinguish them from a more general response to an infection at the biochemical level. For example, suppression of tricarboxylic acid cycle metabolites is only noted for a Schistosoma spp. infection, whereas alterations in metabolites derived from the gut microbiota are common for all the parasitic infections investigated thus far. Finally, we explore how the insight gained with experimental infections could be transferred to human populations and conclude with a section on research needs with regard to molecular diagnostics in parasitology
Publisher Elsevier
ISSN/ISBN 0065-308X
edoc-URL http://edoc.unibas.ch/dok/A5842800
Full Text on edoc No
Digital Object Identifier DOI 10.1016/S0065-308X(10)73012-8
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20627148
ISI-Number WOS:000281780800012
Document type (ISI) Journal Article, Review
Additional Information Also published in: Important helminth infections in southeast Asia. - Amsterdam : Elsevier. - Part B, S. S. 373-404
 
   

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