Logo der Universität Basel

Research Database / FORSCHUNGSDATENBANK 
PRINTDOC
 
Publication 490910 | Verified
 

Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Hox genes and brain development in Drosophila
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 490910
Author(s) Reichert, Heinrich; Bello, Bruno
Author(s) at UniBasel Reichert, Heinrich
Year 2010
Title Hox genes and brain development in Drosophila
Journal Advances in experimental medicine and biology
Volume 689
Pages / Article-Number 145-53
Abstract Hox genes are prominently expressed in the developing brain and ventral ganglia of Drosophila. In the embryonic brain, the Hox genes labial and Deformed are essential for the establishment of regionalized neuronal identity; in their absence cells are generated in the brain but fail to acquire appropriate neuronal features. Genetic analyses reveal that Hox proteins are largely equivalent in their action in embryonic brain development and that their expression is under the control of cross-regulatory interactions among Hox genes that are similar to those found in embryogenesis of trunk segments. Hox genes have a different role in postembryonic brain development. During the larval phase of CNS development, reactivation of specific Hox genes terminates neural proliferation by induction of apoptotic cell death in neural stem cell-like progenitors called neuroblasts. This reactivation process is tightly controlled by epigenetic mechanisms requiring the Polycomb group of genes. Many features of Hox gene action in Drosophila brain development are evolutionarily conserved and are manifest in brain development of vertebrates.
Publisher Springer
ISSN/ISBN 0065-2598
edoc-URL http://edoc.unibas.ch/dok/A5842452
Full Text on edoc No
Digital Object Identifier DOI 10.1007/978-1-4419-6673-5_11
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20795329
ISI-Number WOS:000279545800011
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.371 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
03/05/2024