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Pathogen proteomes during infection : a basis for infection research and novel control strategies
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 490885
Author(s) Bumann, Dirk
Author(s) at UniBasel Bumann, Dirk
Year 2010
Title Pathogen proteomes during infection : a basis for infection research and novel control strategies
Journal Journal of Proteomics
Volume 73
Number 11
Pages / Article-Number 2267-76
Keywords Bacterial infection, Pathogen metabolism, Vaccine antigen identification
Abstract Infectious diseases cause tremendous mortality and morbidity worldwide. Rising antimicrobial resistance and the lack of new drugs cause an increasingly alarming crisis in infectious disease control. New system-level approaches are likely to help understand complex host/pathogen interactions as a basis for rational development of novel antibiotics and vaccines. Proteome analysis of pathogens in infected tissues comprehensively reveals functionally relevant pathogen activities during infection. It also highlights potential targets for antimicrobial chemotherapy as well as promising antigens for vaccination. Integration of these data with complementary large-scale data helps to further prioritize candidates for in-depth experimental analysis. Here, I discuss some of these approaches with a special emphasis on the model pathogen Salmonella.
Publisher Elsevier
ISSN/ISBN 1874-3919
edoc-URL http://edoc.unibas.ch/dok/A5842432
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jprot.2010.08.004
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20797457
ISI-Number WOS:000283903000018
Document type (ISI) Journal Article, Review
 
   

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