Functionalizable Collagen Model Peptides

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Functionalizable Collagen Model Peptides

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	490395
Author(s)	Erdmann, Roman S; Wennemers, Helma
Author(s) at UniBasel	Wennemers, Helma
Year	2010
Title	Functionalizable Collagen Model Peptides
Journal	Journal of the American Chemical Society
Volume	132
Number	40
Pages / Article-Number	13957-9
Abstract	The functionalizability and conformational properties of azidoproline (Azp)-containing collagen model peptides (CMPs) were studied. The results show that (4R)Azp has a similar stabilizing effect on the collagen triple helix as (4R)hydroxyproline and that functionalized CMPs are readily accessible by "click" chemistry. The resulting triazole-functionalized CMPs form stable triple helices, demonstrating that sterically demanding moieties in three symmetry-related positions in all strands are tolerated. The straightforward synthesis and facile functionalizability of the Azp-containing CMPs are intriguing for the development of functional collagen-based materials.
Publisher	American Chemical Society
ISSN/ISBN	0002-7863
edoc-URL	http://edoc.unibas.ch/dok/A5842395
Full Text on edoc	No
Digital Object Identifier DOI	10.1021/ja103392t
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/20849115
ISI-Number	WOS:000282660100003
Document type (ISI)	Journal Article

02/05/2024

Research Database / FORSCHUNGSDATENBANK