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Recent biomimetic and organocatalytic syntheses of α-tocopherol
Journal
Chimia
Volume
64
Number
5
Pages / Article-Number
303-8
Keywords
Chromane, Enantioselectivity, alpha-Tocopherol, Tocopherol cyclase, Vitamin E
Abstract
We report here on our efforts to develop new strategies for the synthesis of alpha-tocopherol, the biologically most significant member of the vitamin E family. This review comprises five new methods to generate the chiral chromane of alpha-tocopherol with overall up to 29% yield from commercially available material and up to 94% de.
