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Asymmetric Synthesis and Biological Activity of nor-α-Tocopherol, a New Vitamin E Analogue
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 480193
Author(s) Chapelat, Julien; Hengartner, Urs; Chougnet, Antoinette; Liu, Kegang; Huebbe, Patricia; Rimbach, Gerald; Woggon, Wolf-D
Author(s) at UniBasel Woggon, Wolf-Dietrich
Year 2011
Title Asymmetric Synthesis and Biological Activity of nor-α-Tocopherol, a New Vitamin E Analogue
Journal ChemBioChem
Volume 12
Number 1
Pages / Article-Number 118-24
Keywords inflammation, nor-tocopherol, tocopherol, vitamins
Abstract The vitamin E analogues (2R,4'R, 8'R)-nor-alpha-tocopherol (94% de) and (2RS,4'R,8'R)-nor-alpha-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-alpha-tocopherol is an anti-inflammatory compound more potent than alpha-tocopherol.
Publisher Wiley-VCH
ISSN/ISBN 1439-4227
edoc-URL http://edoc.unibas.ch/dok/A5842106
Full Text on edoc No
Digital Object Identifier DOI 10.1002/cbic.201000511
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21161968
ISI-Number WOS:000285771200014
Document type (ISI) Journal Article
 
   

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