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The vitamin E analogues (2R,4'R, 8'R)-nor-alpha-tocopherol (94% de) and (2RS,4'R,8'R)-nor-alpha-tocopherol have been synthesized from (all R)-hexahydrofarnesol and phytol, respectively. According to in vitro experiments with murine macrophages nor-alpha-tocopherol is an anti-inflammatory compound more potent than alpha-tocopherol.