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The "Diagnostisches Interview bei psychischen Störungen" (DIPS fur DSM-IV-TR; Schneider & Margraf, 2006) is a structured interview that has been expanded and adapted to DSM-IV-TR criteria. Objective: The purpose of this study was to validate the DIPS for DSM-IV-TR. Methods: The validity of the DIPS diagnoses was verified using a questionnaire battery on a sample of 194 patients from various clinical facilities. Results: Results indicate good validity in the categories of anxiety disorders, mood disorders, somatoform disorders, eating disorders, substance disorders, and for the exclusion of mental disorders. Inadequate validity was found solely for sleep disorders and generalized anxiety disorder. Conclusions: The DIPS for DSM-IV-TR has proven to be a valid tool (except for generalized anxiety disorder and sleep disorders) for use with outpatients and inpatients from psychiatric facilities.