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Natural product based identification of new scaffolds for drug development against HIV
| Project funded by own resources |
| Project title |
Natural product based identification of new scaffolds for drug development against HIV |
| Principal Investigator(s) |
Hamburger, Matthias
Klimkait, Thomas
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| Co-Investigator(s) |
Potterat, Olivier
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| Organisation / Research unit |
Departement Pharmazeutische Wissenschaften / Pharmazeutische Biologie (Hamburger) |
| Project start |
01.01.2010 |
| Probable end |
01.06.2011 |
| Status |
Completed |
| Abstract |
An extract library is screened for antiviral activity against HIV. Active compounds are identified via HPLC-based activity profiling and in-line and off-line spectroscopic characterization. Shortlisted molecules are analyzed for drug-likeness and further characteriezed with respect to their selectivity and putative mode of action.
The project is pursued in collaboration with the Esperanza Medicines Foundation (Chairman Prof. Alex Matter, Director Novartis Institute for Tropical Diseases, Singapore).
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| Financed by |
Other funds
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Published results () |
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ID |
Autor(en) |
Titel |
ISSN / ISBN |
Erschienen in |
Art der Publikation |
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990036 |
Vidal, V; Potterat, O; Louvel, S; Hamy, F; Mojarrab, M; Sanglier, JJ; Klimkait, T; Hamburger, M |
Library-Based Discovery and Characterization of Daphnane Diterpenes as Potent and Selective HIV Inhibitors in Daphne gnidium. |
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J. Nat. Prod. |
Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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Cooperations () |
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ID |
Kreditinhaber |
Kooperationspartner |
Institution |
Laufzeit - von |
Laufzeit - bis |
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462209 |
Hamburger, Matthias |
Thomas Klimkait, Prof |
University of Basel |
01.01.2010 |
01.06.2011 |
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16/04/2024
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