|
Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
|
ID |
4696088 |
Author(s) |
Kröpfl, Julia M; Beltrami, Fernando G; Rehm, Markus; Gruber, Hans-Jürgen; Stelzer, Ingeborg; Spengler, Christina M |
Author(s) at UniBasel |
Kröpfl, Julia Maria
|
Year |
2021 |
Title |
Acute exercise-induced glycocalyx shedding does not differ between exercise modalities, but is associated with total antioxidative capacity. |
Journal |
Journal of science and medicine in sport |
Volume |
24 |
Number |
7 |
Pages / Article-Number |
689-695 |
Keywords |
Glycocalyx; Hematopoietic stem cells; High-intensity interval training; Oxygen radical absorbance capacity; Vascular endothelial cells |
Mesh terms |
Adult; Antioxidants, metabolism; Bicycling, physiology; Endothelial Cells, metabolism; Glycocalyx, metabolism; Hematopoietic Stem Cells, metabolism; Heparitin Sulfate, blood; Humans; Hyaluronic Acid, blood; Male; Oxidative Stress; Running, physiology; Syndecan-1, blood |
Abstract |
Regular physical exercise is known to protect endothelial integrity. It has been proposed that acute exercise-induced changes of the (anti-)oxidative system influence early (glycocalyx shedding) and sustained endothelial activation (shedding of endothelial cells, ECs) as well as endothelial-cell repair by circulating hematopoietic stem and progenitor cells (HPCs). However, results are not conclusive and data in trained participants performing different exercise modalities is lacking.; Eighteen healthy, well-trained participants (9 runners, 9 cyclists; age: 29.7 ± 4.2 yrs) performed a strenuous acute exercise session consisting of 4 bouts of 4-min high-intensity with decreasing power profile and 3-min low-intensity in-between.; Average power/speed of intense phases was 85% of the peak achieved in a previous incremental test. Before and shortly after exercise, total oxidative and antioxidative capacities (TAC), shedding of syndecan-1, heparan sulfate, hyaluronan, ECs, and circulating HPCs were investigated.; TAC decreased from 1.81 ± 0.42 nmol/L to 1.47 ± 0.23 nmol/L post-exercise (p = 0.010) only in runners. Exercise-induced early and sustained endothelial activation were enhanced post-exercise- syndecan-1: 103.2 ± 63.3 ng/mL to 111.3 ± 71.3 ng/mL, heparan sulfate: from 2637.9 ± 800.1 ng/mL to 3197.1 ± 1416.3 ng/mL, both p < 0.05; hyaluronan: 84.3 ± 21.8 ng/mL to 121.4 ± 29.4 ng/mL, ECs: from 6.6 ± 4.5 cells/μL to 9.5 ± 6.2 cells/μL, both p < 0.01; results were not different between exercise modalities and negatively related to TAC concentrations post-exercise. HPC proportions and self-renewal ability were negatively, while EC concentrations were positively associated with circulating hyaluronan concentrations.; These results highlight the importance of the antioxidative system to prevent the endothelium from acute exercise-induced vascular injury - independent of exercise modality - in well-trained participants. Endothelial-cell repair is associated with hyluronan signaling, possibly a similar mechanism as in wound repair. |
ISSN/ISBN |
1878-1861 |
Full Text on edoc |
|
Digital Object Identifier DOI |
10.1016/j.jsams.2021.01.010 |
PubMed ID |
http://www.ncbi.nlm.nih.gov/pubmed/33632661 |
|
|
|
MCSS v5.8 PRO. 0.354 sec, queries - 0.000 sec
©Universität Basel | Impressum
| |
02/05/2024
Research Database / FORSCHUNGSDATENBANK
|