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Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective alienor study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4694328
Author(s)
Gayraud, L.; Mortamais, M.; Schweitzer, C.; de Hoogh, K.; Cougnard-Grégoire, A.; Korobelnik, J. F.; Delyfer, M. N.; Rougier, M. B.; Leffondré, K.; Helmer, C.; Vienneau, D.; Berr, C.; Delcourt, C.
Association of long-term exposure to ambient air pollution with retinal neurodegeneration: the prospective alienor study
Journal
Environmental research
Volume
232
Pages / Article-Number
116364
Abstract
Chronic exposure to air pollution may have adverse effects on neurodegenerative diseases. Glaucoma, the second leading cause of blindness worldwide, is a neurodegenerative disease of the optic nerve, characterized by progressive thinning of the retinal nerve fiber layer (RNFL). We investigated the relationship of air pollution exposure with longitudinal changes of RNFL thickness in the Alienor study, a population-based cohort of residents of Bordeaux, France, aged 75 years or more. Peripapillary RNFL thickness was measured using optical coherence tomography imaging every 2 years from 2009 to 2020. Measurements were acquired and reviewed by specially trained technicians to control quality. Air pollution exposure (particulate matter
