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Development and acceptance of a new adherence monitoring package to identify non-adherent patients with polypharmacy in primary care: a feasibility study.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4683769
Author(s) Dietrich, Fine; Zeller, Andreas; Allemann, Samuel; Arnet, Isabelle
Author(s) at UniBasel Arnet, Isabelle
Zeller, Andreas
Allemann, Samuel
Dietrich, Fine Michèle
Year 2023
Title Development and acceptance of a new adherence monitoring package to identify non-adherent patients with polypharmacy in primary care: a feasibility study.
Journal BMJ Open quality
Volume 12
Number 1
Pages / Article-Number e002155
Keywords Chronic disease management; Compliance; General practice; Pharmacists; Polypharmacy
Mesh terms Humans; Polypharmacy; Feasibility Studies; Heart Failure, drug therapy; Medication Adherence; Primary Health Care

Adherence to pharmacotherapy is crucial to prevent symptom deterioration in chronic diseases. However, non-adherence to chronic treatments is prevalent, especially in polypharmacy. Practical tools to assess adherence to polypharmacy in primary care are missing.; We aimed to develop an Adherence Monitoring Package (AMoPac) for general practitioners (GPs) to identify patient non-adherence. We tested the feasibility and acceptance of AMoPac in the primary healthcare setting.; AMoPac was developed based on peer-reviewed literature. It consists in (1) electronic monitoring of patients' medication intakes for 4 weeks, (2) receiving feedback on intake behaviour by the pharmacist and (3) generating an adherence report to communicate to the GPs. A feasibility study was conducted with heart failure patients. GPs' acceptance of AMoPac was explored with semistructured interviews. Electronic transmission of the reports into the GP's electronic health record along with laboratory reports stating N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels was analysed.; We developed AMoPac and tested its feasibility with six GPs and seven heart failure patients. GPs were satisfied with the adherence report including the pharmaceutical-clinical recommendations. Integrated transmission of adherence reports to GPs was not feasible due to technical incompatibilities. Mean taking adherence was 86.4%±12.8% and three patients had low correct dosing-days (69%, 38% and 36%, respectively). NT-proBNP ranged from 102 to 8561 pg/mL and four patients had elevated values (>1000 pg/mL).; AMoPac is feasible in the primary healthcare setting, excluding the integrated transmission of adherence reports to GPs. The procedure was highly accepted by GPs and patients. AMoPac fills a gap by combining clinical values with adherence data, and therefore, delivers a multifaceted picture of the patient's behaviour. In case of unmet adherence, our tool might facilitate the selection of patient-centred approaches to optimise pharmacological therapies in chronic heart failure patients.; NCT04326101.

ISSN/ISBN 2399-6641
Full Text on edoc
Digital Object Identifier DOI 10.1136/bmjoq-2022-002155
PubMed ID

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