Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Prospective association between depressive symptoms and blood-pressure related outcomes in Kosovo
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4665577
Author(s) Obas, K. A.; Kwiatkowski, M.; Bytyci-Katanolli, A.; Statovci, S.; Jerliu, N.; Ramadani, Q.; Fota, N.; Gerold, J.; Zahorka, M.; Probst-Hensch, N.
Author(s) at UniBasel Obas, Katrina
Kwiatkowski, Marek
Bytyši Katanolli, Ariana
Probst-Hensch, Nicole
Gerold, Jana
Year 2023
Title Prospective association between depressive symptoms and blood-pressure related outcomes in Kosovo
Journal PLOS Glob Public Health
Volume 3
Number 4
Pages / Article-Number e0000851
Abstract Kosovo has the lowest life expectancy in the Western Balkans, where cardiovascular disease (CVD) accounts for over half of all deaths. Depression also contributes to disability in the country, with a prevalence of moderate to severe symptoms reported as high as 42% in the general population. Although the mechanisms are not yet well understood, evidence suggests that depression is an independent risk factor for CVD. Our study assessed the prospective association between depressive symptoms and blood pressure (BP)-related outcomes among primary healthcare users in Kosovo to understand the role of BP in the relationship between depression and CVD. We included 648 primary healthcare users from the KOSCO study. The presence of depressive symptoms was defined as moderate to very severe depressive symptoms (DASS-21 depressive symptoms score >/=14). Multivariable censored regression models assessed prospective associations between baseline depressive symptoms and changes in systolic and diastolic BP while taking hypertension treatment into consideration. Multivariable logistic regression models assessed prospective associations between baseline depressive symptoms and hypertension diagnosis among normotensive patients (n = 226) as well as uncontrolled hypertension in hypertensive patients (n = 422) at follow-up. Depressive symptoms were associated with attenuated diastolic BP (beta = -2.84, 95%-CI -4.64 to -1.05, p = 0.002) over a year of follow-up in our fully adjusted model, although the association with systolic BP (beta = -1.98, 95%-CI -5.48 to 1.28, p = 0.23) did not meet statistical significance. We found no statistically significant association of depressive symptoms with hypertension diagnosis among initially normotensive people (OR = 1.68, 95%-CI 0.41 to 6.98, p = 0.48), nor with hypertension control among initially hypertensive people (OR = 0.69, 95%-CI 0.34 to 1.41, p = 0.31). Our findings are not consistent with increased BP as an underlying mechanism between depression and elevated CVD risk and contribute valuable evidence to cardiovascular epidemiology, where the mechanisms between depression, hypertension and CVD are yet to be elucidated.
ISSN/ISBN 2767-3375 (Electronic)2767-3375 (Linking)
URL https://doi.org/10.1371/journal.pgph.0000851
edoc-URL https://edoc.unibas.ch/94557/
Full Text on edoc Available
Digital Object Identifier DOI 10.1371/journal.pgph.0000851
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/37027380
ISI-Number MEDLINE:37027380
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.551 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
14/04/2024