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Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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ID |
4665186 |
Author(s) |
Hadjas, Lotfi C; Lüscher, Christian; Simmler, Linda D |
Author(s) at UniBasel |
Simmler, Linda
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Year |
2019 |
Title |
Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder. |
Journal |
Scientific reports |
Volume |
9 |
Number |
1 |
Pages / Article-Number |
12061 |
Mesh terms |
Animals; Behavior, Animal; Disease Models, Animal; Genotype; Habits; Locomotion; Mice; Mice, Knockout; Nerve Tissue Proteins, genetics; Obsessive-Compulsive Disorder, diagnosis, etiology; Phenotype; Reward |
Abstract |
Motor behavior can be executed deliberately to achieve specific goals. With repetition, such behavior can become habitual and noncontingent on actions-outcomes. The formation of habits is a natural process that can become pathological, such as in obsessive-compulsive disorder (OCD). The present study used the Sapap3-knockout (KO) mouse model of OCD to assess habit formation based on reward devaluation. We also tested wildtype mice under different training and food-restriction schedules to assess the extent of natural habit formation. We found that Sapap3-KO mice were insensitive to the devaluation of a sucrose reward under conditions in which wildtype littermates were sensitive to devaluation. Moreover, food restriction favored goal-directed action in wildtype mice, whereas mice that were fed ad libitum were more likely to form habitual behavior but nevertheless maintained partly goal-directed lever-press behavior. In conclusion, only Sapap3-KO mice developed behavior that was fully insensitive to reward devaluation, suggesting that pathological habits in OCD patients are recapitulated in the present Sapap3-KO mouse model. In wildtype mice, the extent of habit formation was influenced by the state of satiety during training and the reinforcement schedule. |
ISSN/ISBN |
2045-2322 |
Full Text on edoc |
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Digital Object Identifier DOI |
10.1038/s41598-019-48637-9 |
PubMed ID |
http://www.ncbi.nlm.nih.gov/pubmed/31427755 |
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29/03/2024
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