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Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4665186
Author(s) Hadjas, Lotfi C; Lüscher, Christian; Simmler, Linda D
Author(s) at UniBasel Simmler, Linda
Year 2019
Title Aberrant habit formation in the Sapap3-knockout mouse model of obsessive-compulsive disorder.
Journal Scientific reports
Volume 9
Number 1
Pages / Article-Number 12061
Mesh terms Animals; Behavior, Animal; Disease Models, Animal; Genotype; Habits; Locomotion; Mice; Mice, Knockout; Nerve Tissue Proteins, genetics; Obsessive-Compulsive Disorder, diagnosis, etiology; Phenotype; Reward
Abstract

Motor behavior can be executed deliberately to achieve specific goals. With repetition, such behavior can become habitual and noncontingent on actions-outcomes. The formation of habits is a natural process that can become pathological, such as in obsessive-compulsive disorder (OCD). The present study used the Sapap3-knockout (KO) mouse model of OCD to assess habit formation based on reward devaluation. We also tested wildtype mice under different training and food-restriction schedules to assess the extent of natural habit formation. We found that Sapap3-KO mice were insensitive to the devaluation of a sucrose reward under conditions in which wildtype littermates were sensitive to devaluation. Moreover, food restriction favored goal-directed action in wildtype mice, whereas mice that were fed ad libitum were more likely to form habitual behavior but nevertheless maintained partly goal-directed lever-press behavior. In conclusion, only Sapap3-KO mice developed behavior that was fully insensitive to reward devaluation, suggesting that pathological habits in OCD patients are recapitulated in the present Sapap3-KO mouse model. In wildtype mice, the extent of habit formation was influenced by the state of satiety during training and the reinforcement schedule.

ISSN/ISBN 2045-2322
Full Text on edoc
Digital Object Identifier DOI 10.1038/s41598-019-48637-9
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/31427755
   

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