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Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 4663759
Author(s) Streese, Lukas; Habisch, Hansjörg; Deiseroth, Arne; Carrard, Justin; Infanger, Denis; Schmidt-Trucksäss, Arno; Madl, Tobias; Hanssen, Henner
Author(s) at UniBasel Carrard, Justin
Streese, Lukas
Infanger, Denis
Schmidt-Trucksäss, Arno
Hanssen, Henner
Year 2022
Title Lipoprotein Subclasses Independently Contribute to Subclinical Variance of Microvascular and Macrovascular Health
Journal Molecules
Volume 27
Number 15
Pages / Article-Number 4760
Keywords NMR spectroscopy; cardiovascular risk; lipids; pulse wave velocity; retinal vessel diameters
Mesh terms Biomarkers; Cholesterol, LDL; Humans; Lipoproteins; Lipoproteins, LDL; Pulse Wave Analysis; Triglycerides
Abstract Lipoproteins are important cardiovascular (CV) risk biomarkers. This study aimed to investigate the associations of lipoprotein subclasses with micro- and macrovascular biomarkers to better understand how these subclasses relate to atherosclerotic CV diseases. One hundred and fifty-eight serum samples from the EXAMIN AGE study, consisting of healthy individuals and CV risk patients, were analysed with nuclear magnetic resonance (NMR) spectroscopy to quantify lipoprotein subclasses. Microvascular health was quantified by measuring retinal arteriolar and venular diameters. Macrovascular health was quantified by measuring carotid-to-femoral pulse wave velocity (PWV). Nineteen lipoprotein subclasses showed statistically significant associations with retinal vessel diameters and nine with PWV. These lipoprotein subclasses together explained up to 26% of variation (R2 = 0.26, F(29,121) = 2.80, p < 0.001) in micro- and 12% (R2 = 0.12, F(29,124) = 1.70, p = 0.025) of variation in macrovascular health. High-density (HDL-C) and low-density lipoprotein cholesterol (LDL-C) as well as triglycerides together explained up to 13% (R2 = 0.13, F(3143) = 8.42, p < 0.001) of micro- and 8% (R2 = 0.08, F(3145) = 5.46, p = 0.001) of macrovascular variation. Lipoprotein subclasses seem to reflect micro- and macrovascular end organ damage more precisely as compared to only measuring HDL-C, LDL-C and triglycerides. Further studies are needed to analyse how the additional quantification of lipoprotein subclasses can improve CV risk stratification and CV disease prediction.
Publisher MDPI
ISSN/ISBN 1420-3049
Full Text on edoc Available
Digital Object Identifier DOI 10.3390/molecules27154760
PubMed ID
ISI-Number WOS:000839899500001
Document type (ISI) Journal Article

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