Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
4662262
Author(s)
Seebacher, W.; Kaiser, M.; Mäser, P.; Saf, R.; Pferschy-Wenzig, E. M.; Weis, R.
Author(s) at UniBasel
Kaiser, Marcel Mäser, Pascal
Year
2023
Title
Benzyl- and dibenzyl tetrahydropyridinylidene ammonium salts with antiplasmodial and antitrypanosomal activity
Journal
Monatshefte fu�r Chemie
Volume
154
Number
1
Pages / Article-Number
105-114
Abstract
Several 1-benzyl and 1,3-dibenzyl derivatives of tetrahydropyridinylidene salts with differing electron withdrawing substituents at the aromatic residues have been prepared. In addition, the amine moiety in position 4 was varied. The new compounds were investigated for their antiplasmodial and antitrypanosomal activities as well as for their cytotoxicity. They were characterized using FT-IR, HRMS and NMR spectroscopy. Structure-activity relationships including reported compounds are discussed. Graphical abstract: [Figure not available: see fulltext.]. © 2022, The Author(s).
ISSN/ISBN
0026-9247
URL
https://doi.org/10.1007/s00706-022-03003-w
edoc-URL
https://edoc.unibas.ch/93576/
Full Text on edoc
Available
Digital Object Identifier DOI
10.1007/s00706-022-03003-w
ISI-Number
WOS:000885865600001
Document type (ISI)
Article
MCSS v5.8 PRO. 0.349 sec, queries - 0.000 sec
©Universität Basel | Impressum
|
11/05/2024
Research Database / FORSCHUNGSDATENBANK
