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Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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ID |
4661764 |
Author(s) |
Cajochen, Christian; Jud, Corinne; Münch, Mirjam; Kobialka, Szymon; Wirz-Justice, Anna; Albrecht, Urs |
Author(s) at UniBasel |
Münch, Mirjam
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Year |
2006 |
Title |
Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans. |
Journal |
The European journal of neuroscience |
Volume |
23 |
Number |
4 |
Pages / Article-Number |
1082-6 |
Mesh terms |
Adult; Color; Darkness; Dose-Response Relationship, Radiation; Female; Gene Expression, radiation effects; Humans; Light; Male; Melatonin, metabolism; Mucous Membrane, metabolism, radiation effects; Nuclear Proteins, genetics, metabolism; Period Circadian Proteins; Transcription Factors, genetics, metabolism |
Abstract |
We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders. |
ISSN/ISBN |
0953-816X |
Full Text on edoc |
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Digital Object Identifier DOI |
10.1111/j.1460-9568.2006.04613.x |
PubMed ID |
http://www.ncbi.nlm.nih.gov/pubmed/16519674 |
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