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Association of pulmonary vein isolation and major cardiovascular events in patients with atrial fibrillation.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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ID |
4658553 |
Author(s) |
Girod, Marc; Coslovsky, Michael; Aeschbacher, Stefanie; Sticherling, Christian; Reichlin, Tobias; Roten, Laurent; Rodondi, Nicolas; Ammann, Peter; Auricchio, Angelo; Moschovitis, Giorgio; Kobza, Richard; Badertscher, Patrick; Knecht, Sven; Krisai, Philipp; Marugg, Andrea; Aebersold, Helena; Hennings, Elisa; Serra-Burriel, Miquel; Schwenkglenks, Matthias; Zuern, Christine S; Bonati, Leo H; Conen, David; Osswald, Stefan; Kühne, Michael |
Author(s) at UniBasel |
Schwenkglenks, Matthias
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Year |
2022 |
Title |
Association of pulmonary vein isolation and major cardiovascular events in patients with atrial fibrillation. |
Journal |
Clinical research in cardiology : official journal of the German Cardiac Society |
Volume |
111 |
Number |
9 |
Pages / Article-Number |
1048-1056 |
Keywords |
Adverse outcome events; Atrial fibrillation; Coarsened exact matching; Pulmonary vein isolation |
Mesh terms |
Aged; Atrial Fibrillation, complications, epidemiology, surgery; Catheter Ablation, adverse effects; Female; Heart Failure, epidemiology, surgery; Humans; Ischemic Attack, Transient; Male; Prospective Studies; Pulmonary Veins, surgery; Recurrence; Stroke, epidemiology, etiology; Treatment Outcome |
Abstract |
Patients with atrial fibrillation (AF) face an increased risk of adverse cardiovascular events. Evidence suggests that early rhythm control including AF ablation may reduce this risk.; To compare the risks for cardiovascular events in AF patients with and without pulmonary vein isolation (PVI), we analysed data from two prospective cohort studies in Switzerland (n = 3968). A total of 325 patients who had undergone PVI during a 1-year observational period were assigned to the PVI group. Using coarsened exact matching, 2193 patients were assigned to the non-PVI group. Outcomes were all-cause mortality, hospital admission for acute heart failure, a composite of stroke, transient ischemic attack and systemic embolism (Stroke/TIA/SE), myocardial infarction (MI), and bleedings. We calculated multivariable adjusted Cox proportional-hazards models.; Overall, 2518 patients were included, median age was 66 years [IQR 61.0, 71.0], 25.8% were female. After a median follow-up time of 3.9 years, fewer patients in the PVI group died from any cause (incidence per 100 patient-years 0.64 versus 1.87, HR 0.39, 95%CI 0.19-0.79, p = 0.009) or were admitted to hospital for acute heart failure (incidence per 100 patient-years 0.52 versus 1.72, HR 0.44, 95%CI 0.21-0.95, p = 0.035). There was no significant association between PVI and Stroke/TIA/SE (HR 0.94, 95%CI 0.52-1.69, p = 0.80), MI (HR 0.43, 95%CI 0.11-1.63, p = 0.20) or bleeding (HR 0.75, 95% CI 0.50-1.12, p = 0.20).; In our matched comparison, patients in the PVI group had a lower incidence rate of all-cause mortality and hospital admission for acute heart failure compared to the non-PVI group.; NCT02105844, April 7th 2014. |
ISSN/ISBN |
1861-0692 |
Full Text on edoc |
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Digital Object Identifier DOI |
10.1007/s00392-022-02015-0 |
PubMed ID |
http://www.ncbi.nlm.nih.gov/pubmed/35403852 |
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