Genetically modified malaria parasites as vaccine candidates

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Genetically modified malaria parasites as vaccine candidates

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	4657549
Author(s)	Daubenberger, C.
Author(s) at UniBasel	Daubenberger, Claudia
Year	2023
Title	Genetically modified malaria parasites as vaccine candidates
Journal	Trends in molecular medicine
Volume	29
Number	1
Pages / Article-Number	1-3
Mesh terms	Animals; Humans; Malaria Vaccines, therapeutic use; Sporozoites; Malaria; Liver
Abstract	Induction of sterile immunity against sporozoite and liver stages of malaria is a long-standing aim in vaccine development. Genetically engineered, attenuated sporozoites were systematically evaluated in animal models. Murphy et al. present the first, promising clinical trial of early arresting parasites, PfGAP3KO, confirming safety and demonstrating efficacy against homologous challenge.
ISSN/ISBN	1471-4914
edoc-URL	https://edoc.unibas.ch/92191/
Full Text on edoc	No
Digital Object Identifier DOI	10.1016/j.molmed.2022.11.005
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/36404198
ISI-Number	MEDLINE:36404198
Document type (ISI)	Journal Article

14/05/2024

Research Database / FORSCHUNGSDATENBANK