Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4656046
Author(s) Wittwer, Nina L; Meier, Christoph R; Huber, Carola A; Meyer Zu Schwabedissen, Henriette E; Allemann, Samuel; Schneider, Cornelia
Author(s) at UniBasel Meyer zu Schwabedissen, Henriette
Meier, Christoph R.
Allemann, Samuel
Schneider, Cornelia
Wittwer, Nina Lea
Year 2022
Title Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database.
Journal Pharmacogenomics and personalized medicine
Volume 15
Pages / Article-Number 967-976
Keywords PGx; claims data; drug use; pharmacoepidemiology
Abstract

In Switzerland 167 drugs on the market contain information about pharmacogenetics in their drug label (PGx drug). Preemptive pharmacogenetic testing is reimbursed by health care insurance for only seven drugs (abacavir, carbamazepine, 6-mercaptopurine, azathioprine, 5-fluorouracil, capecitabine, and irinotecan) although, it is proposed to be a cost-effective approach to personalized medicine. The aim of this study was to describe the use of PGx drugs and their corresponding genes in Switzerland.; We identified 90 drugs with dosing recommendations from the Pharmacogenetic Knowledgebase involving 24 genes. We assessed the utilization of those drugs between 2016 and 2020, using claims data from a large Swiss insurance company (Helsana).; Of 841 491 persons with drug claims during the whole study period, 78.7% were exposed to PGx drugs. Ibuprofen, pantoprazole, and tramadol had the highest number of users. Seven genes (; CYP2C19, CYP2C9, CYP2D6, SLCO1B1, HLA-B, MT-RNR1; , and; VKORC1; ) were responsible for over 95% of all potential drug-gene interactions.; The prevalence of PGx drug prescriptions is high in the Swiss population. Therefore, intensified preemptive testing may be a useful option as a substantial amount of the Swiss population might benefit.

ISSN/ISBN 1178-7066
Full Text on edoc
Digital Object Identifier DOI 10.2147/PGPM.S382214
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/36447837
   

MCSS v5.8 PRO. 0.333 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
18/05/2024