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This comprehensive scientific review, available for downloading below, examines the evidence for associations between several adverse health effects and traffic-related air pollution (TRAP). The review, the largest of its type to date, was conducted by a panel of 13 renowned experts who evaluated 353 published scientific reports on traffic pollution and related health effects between 1980 and 2019. HEI appointed the panel in 2018 following the Institute's widely cited 2010 TRAP report. In addition to the systematic review of the epidemiological evidence, this Special Report features a section that addresses important issues related to technologies and emissions from motor vehicles, including a high-level, succinct review on the mechanistic evidence of health effects of exposure to TRAP.