The work programme proposed by the SQUEEZE consortium is a truly interrelated collaboration of leading centres in Europe that have come together for synergy and added value for addressing the objectives in a way that each one alone would not be able to. Within SQUEEZE WP#8, we will develop a novel eHealth-facilitated care model which includes personalised digital biomarkers to increase DMARDs effectiveness through optimized patient’s medication adherence and patient/clinician’s shared decision making. The participative and systematic approach has promising potential to improve the health outcomes of this population and – if proven effective – be a game changer in the lives of people with RA.