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Effectiveness of four different interventions against Schistosoma haematobium in a seasonal transmission setting of Côte d'Ivoire: a cluster randomized trial
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4651787
Author(s) Ouattara, M.; Bassa, F. K.; Diakité, N. R.; Hattendorf, J.; Coulibaly, J. T.; Yao, P. K.; Tian-Bi, Y. T.; Konan, C. K.; Assaré, R. K.; Koné, N.; Guindo-Coulibaly, N.; Utzinger, J.; N'Goran, E. K.
Author(s) at UniBasel Hattendorf, Jan
Coulibaly, Jean
Utzinger, Jürg
Year 2022
Title Effectiveness of four different interventions against Schistosoma haematobium in a seasonal transmission setting of Côte d'Ivoire: a cluster randomized trial
Journal Clinical infectious diseases
Volume 74
Number 12
Pages / Article-Number 2181-2190
Keywords Cote d'Ivoire; Schistosoma haematobium; Schistosomiasis; interruption of transmission; seasonal transmission
Mesh terms Animals; Child; Cote d'Ivoire, epidemiology; Humans; Praziquantel, therapeutic use; Prevalence; Schistosoma haematobium; Schistosomiasis, drug therapy; Schistosomiasis haematobia, prevention & control; Seasons
Abstract BACKGROUND: Annual mass drug administration (MDA) using praziquantel is the cornerstone of schistosomiasis morbidity control, but is not sufficient to interrupt transmission. We implemented a cluster-randomized trial to compare the effectiveness of four different intervention packages to interrupt transmission of Schistosoma haematobium in a seasonal transmission setting of Cote d'Ivoire. METHODS: Sixty-four localities with a S. haematobium prevalence in school children aged 13-14 years above 4% were randomly assigned to one of four intervention arms over a 3-year period: (1) the current standard strategy consisting of annual MDA before peak of transmission; (2) annual MDA after peak of transmission; (3) biannual MDA; and (4) standard MDA combined with snail control. The primary outcome was prevalence and intensity of S. haematobium infection in children aged 9-12 years 1 year after the final intervention, using urine filtration performed by experienced microscopists. RESULTS: By study end, we observed the lowest S. haematobium prevalence in the biannual MDA, compared to the standard treatment arm (0.6% vs. 7.5%; odds ratio [OR] = 0.07, 95% confidence interval [CI] = 0.02 to 0.24). The prevalence in arms 2 and 4 was about 3.5%, which was not statistically significantly different from the standard strategy (both ORs 0.4, 95% CI = 0.1 to ~1.8). New cases of infection were still observed in all arms at study end. CONCLUSIONS: Biannual MDA was the only regimen that outperformed the standard treatment. All strategies resulted in decreased prevalence of infection, however none of them was able to interrupt transmission of S. haematobium within a 3-year period.
ISSN/ISBN 1058-4838
URL https://doi.org/10.1093/cid/ciab787
edoc-URL https://edoc.unibas.ch/90733/
Full Text on edoc Available
Digital Object Identifier DOI 10.1093/cid/ciab787
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/34519344
ISI-Number WOS:000789316100001
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

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20/06/2024