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Evaluating endocrine disrupting chemicals and mixtures for ovarian cell toxicity and assessing a potential susceptibility factor
| Third-party funded project |
| Project title |
Evaluating endocrine disrupting chemicals and mixtures for ovarian cell toxicity and assessing a potential susceptibility factor |
| Principal Investigator(s) |
Bouitbir, Jamal
Odermatt, Alex
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| Organisation / Research unit |
Departement Pharmazeutische Wissenschaften,
Departement Pharmazeutische Wissenschaften / Molecular and Systems Toxicology (Odermatt) |
| Department |
Departement Pharmazeutische Wissenschaften,
Departement Pharmazeutische Wissenschaften / Molecular and Systems Toxicology (Odermatt) |
| Project start |
01.01.2023 |
| Probable end |
31.01.2025 |
| Status |
Active |
| Abstract |
We are assessing individual effects of bisphenol-A (BPA), phthalates and the respective replacement substances on ovarian cell toxicity. The project focuses on three parts: 1) assess disturbances of endoplasmic reticulum (ER) functions and evaluate a role for ER-stress by BPA, phthalates and the respective replacement substances, 2) investigate, if time allows, mixture effects on ovarian toxicity by focusing on ER functions, cellular stress and steroidogenesis, and 3) evaluate hexose-6-phosphate dehydrogenase (H6PD) as susceptibility factor of ovarian toxicity. |
| Financed by |
Foundations and Associations
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| Follow-up project of |
4627322 Ovarian toxicity of phthalates, bisphenol A and their substitutes
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27/04/2024
Research Database / FORSCHUNGSDATENBANK
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