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Effects of school-based physical activity and multi-micronutrient supplementation intervention on growth, health and wellbeing of schoolchildren in three African countries: The KaziAfya study
Project funded by own resources
Project title Effects of school-based physical activity and multi-micronutrient supplementation intervention on growth, health and wellbeing of schoolchildren in three African countries: The KaziAfya study
Principal Investigator(s) Gerber, Markus
Co-Investigator(s) Utzinger, Jürg
Steinmann, Peter
Probst-Hensch, Nicole
Bonfoh, Bassirou
Masanja, Honorati
Walter, Cheryl
Long, Kurt
Project Members Lang, Christin
Beckmann, Johanna
Nqweniso, Siphesihle
Finda, Marcelina
Troré, Sylvain
Coulibaly, Jean
Daouda, Dao
Okumo, Fredros
Minja, Elihaika
Organisation / Research unit Departement Sport, Bewegung und Gesundheit / Sport und psychosoziale Gesundheit (Gerber)
Project Website https://www.kaziafya.org/
Project start 01.01.2018
Probable end 30.06.2023
Status Completed
Abstract

Background: In low- and middle-income countries, infectious diseases remain a key public health issue. Additionally, non-communicable diseases are a rapidly growing public health problem that impose a considerable burden on population health. One way of addressing this dual disease burden is to incorporate (lifestyle) health promotion measures within the education sector. In the planned study, we will (i) assess and compare physical activity, physical fitness, micronutrient status, body composition, infections with soil-transmitted helminths and Schistosoma mansoni, malaria, inflammatory and cardiovascular health risk markers, cognitive function, health-related quality of life, and sleep in schoolchildren in Côte d’Ivoire, South Africa and Tanzania; (ii) determine the bi- and multivariate associations between these variables; and (iii) examine the effects of a school-based health intervention that consists of physical activity, multi-micronutrient supplementation, or both.

Methods: The study is designed as a cluster randomised, double-blind, placebo-controlled trial with a 2x2 factorial design.  Data will be obtained at three time points; at baseline, 9 months and 21 months after baseline assessment. In each country, 1320 primary schoolchildren from grades 1-4 will be recruited. At each school, classes will be randomly assigned to one of four interventions: (i) physical activity; (ii) multi-micronutrient supplementation; (iii) physical activity plus multi-micronutrient supplementation; and (iv) no intervention serving as control. A placebo product will be given to all children who do not receive multi-micronutrient supplementation. After written informed consent by parents/guardians, children will be subjected to anthropometric, clinical, parasitological and physiological assessment. Additionally, fitness tests will be performed, and children will wear an accelerometer device for 7 days to objectively assess physical activity. Children infected with S. mansoni and soil-transmitted helminths will receive deworming drugs according to national policies. Health and nutrition education will be provided to the whole study population independently of study arm allocation.

Discussion: The planned project builds on the experience of a previous intervention study among South African primary schoolchildren. The present study involves three African countries with different social-ecological contexts, in order to investigate whether results are generalisable across the continent.

Trial registration: The study was registered on the 09 August 2018 with ISRCTN https://doi.org/10.1186/ISRCTN29534081

Keywords children; Côte d’Ivoire; dual disease burden; health; multi-micronutrient supplementation; placebo; physical activity; South Africa; Tanzania; wellbeing
Financed by Other funds

Published results ()

  ID Autor(en) Titel ISSN / ISBN Erschienen in Art der Publikation
4622026  Gerber, Markus; Lang, Christin; Beckmann, Johanna; du Randt, Rosa; Gall, Stefanie; Seelig, Harald; Long, Kurt Z.; Ludyga, Sebastian; Müller, Ivan; Nienaber, Madeleine; Nqweniso, Siphesihle; Pühse, Uwe; Steinmann, Peter; Utzinger, Jürg; Walter, Cheryl  How are academic achievement and inhibitory control associated with physical fitness, soil-transmitted helminth infections, food insecurity and stunting among South African primary schoolchildren?  1471-2458  BMC Public Health  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4622029  Gerber, Markus; Lang, Christin; Beckmann, Johanna; Degen, Jan; du Randt, Rosa; Gall, Stefanie; Long, Kurt Z.; Müller, Ivan; Nienaber, Madeleine; Steinmann, Peter; Pühse, Uwe; Utzinger, Jürg; Nqweniso, Siphesihle; Walter, Cheryl  Associations Between Household Socioeconomic Status, Car Ownership, Physical Activity, and Cardiorespiratory Fitness in South African Primary Schoolchildren Living in Marginalized Communities  1543-3080 ; 1543-5474  Journal of Physical Activity and Health  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4642207  Beckmann, Johanna; Lang, Christin; du Randt, Rosa; Gresse, Annelie; Long, Kurt Z.; Ludyga, Sebastian; Müller, Ivan; Nqweniso, Siphesihle; Pühse, Uwe; Utzinger, Jürg; Walter, Cheryl; Gerber, Markus  Prevalence of Stunting and Relationship between Stunting and Associated Risk Factors with Academic Achievement and Cognitive Function: A Cross-Sectional Study with South African Primary School Children  1661-7827 ; 1660-4601  International Journal of Environmental Research and Public Health  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4642216  Elihaika G. Minja, Johnson K. Swai; Winifrida Mponzi, Halfan Ngowo; Fredros Okumu, Markus Gerber; Uwe Pühse, Kurt Z. Long; Jürg Utzinger, Christin Lang; Johanna Beckmann, Marceline Finda  Dietary diversity among households living in Kilombero district, in Morogoro region, South-Eastern Tanzania    Journal of agriculture and food research  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
4649601  Beckmann, Johanna; Nqweniso, Siphesihle; Ludyga, Sebastian; du Randt, Rosa; Gresse, Annelie; Long, Kurt Z.; Nienaber, Madeleine; Seelig, Harald; Pühse, Uwe; Steinmann, Peter; Utzinger, Jürg; Walter, Cheryl; Gerber, Markus; Lang, Christin  Evaluation of a Physical Activity and Multi-Micronutrient Intervention on Cognitive and Academic Performance in South African Primary Schoolchildren  2072-6643  Nutrients  Publication: JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) 
   

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