Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 4648844
Author(s) Frei, Irina C.; Weissenberger, Diana; Ritz, Danilo; Heusermann, Wolf; Colombi, Marco; Shimobayashi, Mitsugu; Hall, Michael N.
Author(s) at UniBasel Hall, Michael N.
Year 2022
Year: comment 2022
Title Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis
Journal Molecular metabolism
Volume 65
Pages / Article-Number 101580
Keywords Adipose tissue; CGRP; Diabetes; Neuropathy; Sensory nervous system; Whole-body energy homeostasis; mTORC2
Abstract Adipose tissue, via sympathetic and possibly sensory neurons, communicates with the central nervous system (CNS) to mediate energy homeostasis. In contrast to the sympathetic nervous system, the morphology, role and regulation of the sensory nervous system in adipose tissue are poorly characterized.; Taking advantage of recent progress in whole-mount three-dimensional imaging, we identified a network of calcitonin gene-related protein (CGRP)-positive sensory neurons in murine white adipose tissue (WAT). We found that adipose mammalian target of rapamycin complex 2 (mTORC2), a major component of the insulin signaling pathway, is required for arborization of sensory, but not of sympathetic neurons. Time course experiments revealed that adipose mTORC2 is required for maintenance of sensory neurons. Furthermore, loss of sensory innervation in WAT coincided with systemic insulin resistance. Finally, we established that neuronal protein growth-associated protein 43 (GAP43) is a marker for sensory neurons in adipose tissue.; Our findings indicate that adipose mTORC2 is necessary for sensory innervation in WAT. In addition, our results also suggest that WAT may affect whole-body energy homeostasis via sensory neurons.
Publisher Elsevier
ISSN/ISBN 2212-8778
edoc-URL https://edoc.unibas.ch/89825/
Full Text on edoc Available
Digital Object Identifier DOI 10.1016/j.molmet.2022.101580
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/36028121
ISI-Number MEDLINE:36028121
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.538 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
29/03/2024